{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:31Z","timestamp":1786977151197,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Six previously unreported papulacandins, namely pestiorosins A\u2013F (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>6<\/jats:bold>\n                    ), were isolated from the fermentation products of the fungus\n                    <jats:italic>Pestalotiopsis rosea<\/jats:italic>\n                    YNJ21 isolated from the fruitbody of\n                    <jats:italic>Amanita exitialis<\/jats:italic>\n                    . The structures of these compounds, along with a known compound called pestiocandin (\n                    <jats:bold>7<\/jats:bold>\n                    ), were determined using MS, NMR data, and modified Mosher's method. All compounds exhibited significant antifungal activity against\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , with MIC values ranging from 0.06 to 2.00\u2005\u03bcg\/mL. In terms of cytotoxicity assays, compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    demonstrated moderate inhibitory activity against human breast cancer MCF\u20107 cells with IC50 values of 24.50 and 16.83\u2005\u03bcM, respectively. On the other hand, compound\n                    <jats:bold>7<\/jats:bold>\n                    displayed similar levels of inhibitory activity against mice microglial BV2 cells with an IC50 value of 24.51\u2005\u03bcM.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401921","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T04:40:03Z","timestamp":1725856803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pestiorosins A\u2013F, New Papulacandins Isolated from the Fungus\n                    <i>Pestalotiopsis rosea<\/i>\n                    YNJ21"],"prefix":"10.1002","volume":"22","author":[{"given":"Yue","family":"Lu","sequence":"first","affiliation":[{"name":"School of Pharmacy Changchun University of Chinese Medicine  Changchun 130117 China"},{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hua","family":"Duan","sequence":"additional","affiliation":[{"name":"School of Pharmacy Changchun University of Chinese Medicine  Changchun 130117 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Shuai","family":"Kang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2010Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You\u2010Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-1508","authenticated-orcid":false,"given":"Chang\u2010Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Institute of Pharmacology and Toxicology  Beijing 100850 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_9_1_1","first-page":"860","volume":"34","author":"Chen P. 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