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The chemical investigation of the mangrove\u2010derived <jats:italic>Streptomyces sundarbansensis<\/jats:italic> 06037, led to the discovery of two previously undescribed enone fatty acids (<jats:bold>1<\/jats:bold>\u2013<jats:bold>2<\/jats:bold>), one new phenylpropionate derivate (<jats:bold>3<\/jats:bold>), along with the isolation of the ten known components (<jats:bold>4<\/jats:bold>\u2013<jats:bold>13<\/jats:bold>). Those chemical structures of isolates were elucidated on the basis of the analysis of diverse spectroscopic data. Initial anti\u2010inflammatory tests of <jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold> in lipopolysaccharide (LPS)\u2010activated RAW 264.7 murine macrophage cells revealed that compound <jats:bold>1<\/jats:bold> possess significant inhibitory effect on the production of Nitro oxidase (NO), with the IC<jats:sub>50<\/jats:sub> value around 15.33\u00b11.32\u2005\u03bcM, together with the suppression of NF\u2010\u03baB phosphorylation and reducing the release of oxygen species (ROS) in RAW 264.7 macrophages, those results indicated that compound <jats:bold>1<\/jats:bold> may exert its anti\u2010inflammatory activity through a reduction in ROS level and the suppression of NF\u2010\u03baB activation pathway.<\/jats:p>","DOI":"10.1002\/cbdv.202401946","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T05:50:14Z","timestamp":1729662614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti\u2010inflammatory Fatty Acid Derivatives From Mangrove\u2010derived Actinomycetes <i>Streptomyces<\/i> sp."],"prefix":"10.1002","volume":"22","author":[{"given":"Cheng","family":"Ge","sequence":"first","affiliation":[{"name":"College of Pharmacy Nantong University  Nantong 226001 P.R. 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