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The bioactive compounds of <jats:italic>C. erectus<\/jats:italic> leaves were isolated and identified by GC\/MS and LC\u2010ESI\u2010MS analysis. Malondialdehyde (MDA), reduced glutathione (GSH), superoxide dismutase (SOD), tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), interleukin\u20106 (IL\u20106), amyloid\u2010\u03b2\u2010peptide (A\u03b2\u2010peptide), tau protein, acetylcholinesterase (AChE), serotonin (5\u2010HT), dopamine (DA) and nor\u2010adrenaline (NE) levels were estimated. The neuromuscular strength, memory behavior and histopathological examination of cerebral cortex region were also conducted. Forty\u2010three compounds were characterized from the non\u2010polar fraction of <jats:italic>C. erectus L<\/jats:italic>. leaves extract and nineteen compounds were identified from the defatted extract. AlCl<jats:sub>3<\/jats:sub>\u2010 induction caused significant elevation of brain oxidative stress, A\u03b2\u2010peptide, tau protein, IL\u20106, TNF\u2010\u03b1 and AChE levels. A significant decrease in 5\u2010HT, ND and DA levels were noticed. Additionally, AlCl<jats:sub>3<\/jats:sub> reduced neuromuscular strength and compromised memory function. Treatment of AlCl3\u2010 induced rats with <jats:italic>C. erectuse<\/jats:italic> extract ameliorated these selected parameters by variable degrees. In conclusion, <jats:italic>C. erectus<\/jats:italic> protects against AlCl<jats:sub>3<\/jats:sub>\u2010 induced AD in rats through its antioxidant, anti\u2010inflammatory, and antineural damage. [Correction added on 3 December 2024, after first online publication: The term \u201cantineutron\u201d was corrected to \u201cantineural\u201d in the preceding sentence.]. It could be considered as a new nutraceutical agent for attenuating symptoms associated with Alzheimer's disease.<\/jats:p>","DOI":"10.1002\/cbdv.202401960","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T12:34:34Z","timestamp":1728131674000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GC\/MS and LC\u2010ESI\u2010MS Analysis of <i>Conocarpus erectus<\/i> Leaves Extract <i>via<\/i> Regulating Amyloid\u2010\u03b2\u2010Peptide, Tau Protein, Neurotransmitters, Inflammation and Oxidative Stress against AlCl<sub>3<\/sub>\u2010Induced Alzheimer's Disease in Rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Noha N.","family":"Nasr","sequence":"first","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre  Dokki, Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M.","family":"El\u2010Hagrassi","sequence":"additional","affiliation":[{"name":"Phytochemistry and Plant Systematic Department National Research Centre  33 El-Buhouth St. Dokki, Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yomna R.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre  Dokki, Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3643-5842","authenticated-orcid":false,"given":"Manal A.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Chemistry National Research Centre  Dokki, Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"issue":"417","key":"e_1_2_10_1_1","first-page":"1","volume":"28","author":"Jadhav R.","year":"2023","journal-title":"Molecules"},{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61349-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152711795563976"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006189"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr277"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14052"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-200421070-00004"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1201632109"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2013.10.008"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2009.07.027"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082561"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2004.07.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210793176572"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics11060509"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2018.01.008"},{"key":"e_1_2_10_16_1","first-page":"468","volume":"6","author":"Beheshti S.","year":"2016","journal-title":"Avicenna J. 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