{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T14:56:10Z","timestamp":1791125770205,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>A series of Triclosan\u2010based hybrids and their Schiff base derivatives with isoniazid were designed through in silico modeling and synthesized using copper\u2010catalyzed azide\u2010alkyne cycloaddition (CuAAC) reaction. These compounds were then evaluated against both <jats:italic>Mycobacterium tuberculosis<\/jats:italic> (<jats:italic>Mtb<\/jats:italic>) and <jats:italic>Mycobacterium abscessus<\/jats:italic> (<jats:italic>Mab<\/jats:italic>). However, none of the synthesized hybrids exhibited significant growth inhibition, with minimum inhibitory concentration (MIC) values consistently exceeding 100\u00a0\u00b5g\/mL. To further investigate these findings, we conducted mechanistic studies including thermogravimetric analysis (TGA) and UV\u2013vis stability tests. TGA demonstrated thermal stability of the Schiff bases up to 270\u00b0C, while UV\u2013vis analysis confirmed their chemical resilience across a wide pH spectrum, showing resistance to hydrolysis under acidic and basic conditions. The lack of observed antimicrobial activity may be attributed to the high lipophilicity of these molecules, as indicated by LogP values exceeding 5, which could limit their bioavailability. These findings suggest that although combining triclosan and isoniazid holds potential, further optimization of this hybrid strategy is necessary to improve efficacy.<\/jats:p>","DOI":"10.1002\/cbdv.202401967","type":"journal-article","created":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T07:49:15Z","timestamp":1731570555000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Design, Synthesis, and Anti\u2010Mycobacterial Evaluation of Triclosan\u2010Isoniazid Hybrids"],"prefix":"10.1002","volume":"22","author":[{"given":"Nikita","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of chemistry Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shefali","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"Department of chemistry Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francoise","family":"Roquet\u2010Baneres","sequence":"additional","affiliation":[{"name":"Centre national de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM) Universit\u00e9 de Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Kremer","sequence":"additional","affiliation":[{"name":"Centre national de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM) Universit\u00e9 de Montpellier Montpellier France"},{"name":"INSERM, IRIM Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6164-7161","authenticated-orcid":false,"given":"Vipan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of chemistry Guru Nanak Dev University Amritsar Punjab India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"203","article-title":"Synthesis, Characterization And Evaluation Of Indole Clubbed Isoniazid Derivatives Against Tuberculosis","volume":"19","author":"Shad M.","year":"2023","journal-title":"Ijoe"},{"key":"e_1_2_9_3_1","unstructured":"Global tuberculosis report (2023) accessed May 22 2024 Global tuberculosis report 2023 (who.int)."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00731-y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143125"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9082541"},{"key":"e_1_2_9_7_1","first-page":"210","article-title":"Nontuberculous Mycobacterial Pulmonary Infections","volume":"6","author":"Johnson M. 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