{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:04:29Z","timestamp":1787612669006,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260833"],"award-info":[{"award-number":["82260833"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005329","name":"Natural Science Foundation of Guizhou Province","doi-asserted-by":"publisher","award":["QKHJ-ZK(2022)YB503"],"award-info":[{"award-number":["QKHJ-ZK(2022)YB503"]}],"id":[{"id":"10.13039\/501100005329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Funtumine is a pregnene\u2010type steroidal alkaloid exhibiting moderate anticancer activity. To discover novel natural product\u2010based anticancer drugs, a series of novel funtumine amide\/sulfonamide derivatives were papered and identified using spectroscopic techniques. Additionally, the structures of compounds\n                    <jats:bold>2j<\/jats:bold>\n                    ,\n                    <jats:bold>3a<\/jats:bold>\n                    , and\n                    <jats:bold>4k<\/jats:bold>\n                    were further confirmed through X\u2010ray diffraction analysis. Biological activity experiments conducted against three cancer cell lines revealed that several of the synthesized compounds demonstrated inhibition activities comparable to or exceeding those of the commercial anticancer agent, 5\u2010Fluorouracil. Especially compound\n                    <jats:bold>4i<\/jats:bold>\n                    demonstrated a notably strong growth inhibitory effect on HePG2 (IC\n                    <jats:sub>50<\/jats:sub>\n                    =14.89\u2005\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M) and HCT116 (IC\n                    <jats:sub>50<\/jats:sub>\n                    =15.67\u2005\n                    <jats:italic>\u03bc<\/jats:italic>\n                    M) cell lines, while exhibiting minimal cytotoxicity towards human normal BEAS\u20102B cells. Preliminary structure\u2010activity relationships (SARs) analysis indicated that the conversion of the carbonyl group at the C\u201020 position of funtumine to a hydroxyl group could yield more potent compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202401971","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T11:25:08Z","timestamp":1728473108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Natural Products\u2010Based Anticancer Agents: Synthesis and Anticancer Activities of Funtumine Amide\/Sulfonamide Derivatives"],"prefix":"10.1002","volume":"22","author":[{"given":"Lang","family":"Wu","sequence":"first","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0685-0420","authenticated-orcid":false,"given":"Xiang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"He","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang 550025 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13659-022-00345-0"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/b704958g"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200690102"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.06.017"},{"key":"e_1_2_9_5_1","first-page":"591","volume":"46","author":"Li W.","year":"2007","journal-title":"Agrochemicals"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(01)00424-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50068a041"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2016.01.018"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(99)00111-2"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.03.021"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf101410d"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(81)85237-5"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50069a002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01493"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880200701538690"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200490100"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2004.08.003"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2006.09.009"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2013.02.006"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr510"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880200903440211"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0OB00770F"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja057404h"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.04.038"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2011.04.016"},{"key":"e_1_2_9_26_1","first-page":"337","volume":"7","author":"Bailly C.","year":"2020","journal-title":"J. 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