{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T18:34:17Z","timestamp":1792694057936,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T00:00:00Z","timestamp":1732320000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32060627"],"award-info":[{"award-number":["32060627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22207021"],"award-info":[{"award-number":["22207021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260686"],"award-info":[{"award-number":["82260686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty\u2010eight novel butylphthalide\u2010hydroxycinnamic acid hybrid derivatives were designed and synthesized to discover effective antiplatelet agglutination drugs. Among these compounds, <jats:bold>3\u2009o<\/jats:bold> gave the optimal inhibitory activity against AA\u2010induced platelet aggregation <jats:italic>in\u2005vitro<\/jats:italic> and also exhibited better inhibition than the precursor 3\u2010n\u2010butylphthalide (NBP) against thrombin\u2010induced platelet contraction, carrageenan\u2010induced tail thrombosis, and FeCl<jats:sub>3<\/jats:sub>\u2010induced common carotid artery thrombosis. Further investigations on the anti\u2010ischemic stroke activity revealed that compound <jats:bold>3\u2009o<\/jats:bold> exhibited a remarkable protective effect against ischemic\/reperfusion brain injury. The PAMPA\u2010BBB permeability and liver microsomal stability tests indicated that compound <jats:bold>3\u2009o<\/jats:bold> could traverse the blood\u2010brain barrier and possessed favorable metabolic stability. This research provides a new candidate compound for treating and preventing cerebrovascular diseases caused by thrombosis.<\/jats:p>","DOI":"10.1002\/cbdv.202402022","type":"journal-article","created":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T08:51:48Z","timestamp":1732351908000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Design and Synthesis of Butylphthalide\u2010Hydroxycinnamic Acid Hybrid Derivatives as Potential Antiplatelet Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Ya","family":"Yang","sequence":"first","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taigui","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyang","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5607-3813","authenticated-orcid":false,"given":"Lingling","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Pharmacy Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D Guizhou Provincial Key Laboratory of Pathogenesis and Drug Research on Common Chronic Diseases Guizhou Medical University  Guiyang 550004 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,23]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac268"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03986.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/10600280211073009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313155"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.06.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.06.090"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4OB00830H"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.36.4.1831"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.18994"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06367-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.01.005"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1508.08095"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1963.sp007185"},{"key":"e_1_2_9_14_1","first-page":"1064","volume":"9","author":"Jansen E. E.","year":"2021","journal-title":"Biomedicine"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112462"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.04.010"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2003.08.012"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119663"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.11.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.04.048"},{"key":"e_1_2_9_21_1","volume":"19","author":"Yu Q. Y.","year":"2022","journal-title":"Chem. Biodiversity"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2023.107034"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:26:05Z","timestamp":1742711165000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,23]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cbdv.202402022"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402022","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,23]]},"assertion":[{"value":"2024-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402022"}}