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A facile method was employed to efficiently synthesize new pyrazolo[1,5\u2010<jats:italic>a<\/jats:italic>]pyrimidines in 84\u201393\u2009% yields by reacting 4\u2010benzyl\u20101<jats:italic>H<\/jats:italic>\u2010pyrazole\u20103,5\u2010diamine with the respective \u03b1,\u03b2\u2010unsaturated ketones. The reaction was carried out in ethanol containing 1.2 equivalents of potassium hydroxide at reflux for 5\u20136\u2005h. The new products are attached to a para\u2010substituted aryl group with variable electronic properties at pyrazolopyrimidine\u2010C5, in addition to one of three units at C7, namely phenyl, thiophen\u20102\u2010yl, or furan\u20102\u2010yl units. A wide spectrum of antibacterial activity was displayed by the new pyrimidines against six different bacterial strains. In general, pyrimidines attached to furan\u20102\u2010yl units at C7, in addition to another aryl unit at C5, attached to 4\u2010Me or 4\u2010OMe groups, demonstrate significant antibacterial activity, particularly against <jats:italic>S. aureus<\/jats:italic> strain. They had MIC\/MBC of 2.5\/5.1 and 2.4\/4.9\u2005\u03bcM, respectively, which exceeded that of ciprofloxacin. Moreover, they demonstrate more effective MRSA inhibitory activity than linezolid, with MIC\/MBC values up to 4.9\/19.7 and 2.4\/19.7\u2005\u03bcM against MRSA ATCC:33591 and ATCC:43300 strains, respectively.<\/jats:p>","DOI":"10.1002\/cbdv.202402031","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T18:19:14Z","timestamp":1726597154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["MRSA Inhibitory Activity of Some New Pyrazolo[1,5\u2010<i>a<\/i>]pyrimidines Linked to Arene and\/or Furan or Thiophene Units"],"prefix":"10.1002","volume":"22","author":[{"given":"Mohamed A. A.","family":"Elneairy","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science Cairo University  Giza 12613 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad G. 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