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Interesting analogs of thiazolo[3,2\u2010<jats:italic>a<\/jats:italic>]quinazoline <jats:bold>713<\/jats:bold> where obtained when hexahydroquinazoline\u20102(<jats:italic>1H<\/jats:italic>)\u2010thione <jats:bold>4<\/jats:bold> reacted with 1,2\u2010dibromoethane, chloroacetyl chloride, bromoacetic acid, bromoacetic acid\/4\u2010chlorobenzaldehyde, 2\u2010bromopropionic acid, ethyl bromo cyanoacetate, and\/or bromomalononitrile; respectively. While triazolo[4,3\u2010<jats:italic>a<\/jats:italic>] quinazoline <jats:bold>14<\/jats:bold>\u2013<jats:bold>16<\/jats:bold> were created when 2\u2010hydrazinylhexahydroquinazoline <jats:bold>6<\/jats:bold> reacted with triethyl orthoformate, acetic anhydride, and carbon disulfide respectively. Numerous spectroscopy tests, including FT\u2010IR, NMR (<jats:sup>1<\/jats:sup>H &amp;<jats:sup>13<\/jats:sup> C), and MS spectrum, proved all the newly produced analogs. Additionally, the new analogs were examined for their antibacterial and antifungal properties against <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Candida albicans<\/jats:italic>. It was discovered that triazolo[4,3\u2010<jats:italic>a<\/jats:italic>] quinazoline analogs <jats:bold>14<\/jats:bold>\u2013<jats:bold>16<\/jats:bold> have superior bacterial and fungal activity when compared to the corresponding conventional doses of Streptomycin andGriseofulvin. Towards <jats:italic>Candida albicans<\/jats:italic>; compounds <jats:bold>14<\/jats:bold>, <jats:bold>15<\/jats:bold>, and <jats:bold>16<\/jats:bold> increase activity with 1.14\u2009%, 1.15\u2009%, and 1.21\u2009%, respectively more than griseofulvin.While, for <jats:italic>Staphylococcus aureus<\/jats:italic>; compounds <jats:bold>14<\/jats:bold>, <jats:bold>15<\/jats:bold>, and <jats:bold>16<\/jats:bold> increase activity with 1.5\u2009%, 1.5\u2009%, and 1.7\u2009%, respectively more than streptomycin. Morever, for <jats:italic>Escherichia coli<\/jats:italic>; compounds <jats:bold>14<\/jats:bold>, <jats:bold>15<\/jats:bold>, and <jats:bold>16<\/jats:bold> increase activity with 1.19\u2009%, 1.21\u2009%, and 1.22\u2009%, respectively more than streptomycin. Finally, structure activity relationships show that quinazoline derivatives exhibit higher activity when fused to pyrazole ring <jats:bold>14\u201316<\/jats:bold> as compared when fused thiophene ring <jats:bold>7\u201313<\/jats:bold>.<\/jats:p>","DOI":"10.1002\/cbdv.202402042","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T12:29:10Z","timestamp":1726144150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Design, Synthesis, Antibacterial, and Antifungal Evaluation of a New Series of Quinazoline \u2013 Thiazole and\/or Quinazoline \u2013 Triazole Hybrids as Bioactive Heterocycles"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-8195","authenticated-orcid":false,"given":"Mahmoud","family":"El\u2010Shahat","sequence":"first","affiliation":[{"name":"Photochemistry Department Chemical Industries Research Institute National Research Centre  Scopus affiliation ID 60014618, 33 EL Buhouth St. Dokki, Giza 12622 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nashwa","family":"Tawfek","sequence":"additional","affiliation":[{"name":"Photochemistry Department Chemical Industries Research Institute National Research Centre  Scopus affiliation ID 60014618, 33 EL Buhouth St. Dokki, Giza 12622 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaa I.","family":"El\u2010Sofany","sequence":"additional","affiliation":[{"name":"Photochemistry Department Chemical Industries Research Institute National Research Centre  Scopus affiliation ID 60014618, 33 EL Buhouth St. Dokki, Giza 12622 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"\u00a0"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crcon.2024.100222"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jece.2020.104107"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2022.102577"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.172"},{"key":"e_1_2_7_6_1","unstructured":"M. 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