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The anti\u2010inflammatory effect of the most active derivative, <jats:bold>14e<\/jats:bold> (41.82\u2009%), was dose\u2010dependent and higher than the values for celecoxib (31.82\u2009%). Compound <jats:bold>14e<\/jats:bold> was almost non\u2010toxic and inhibited different concentrations of nitric oxide (NO). The western blotting results demonstrated that cyclooxygenase\u20102 (COX\u20102) expression was elevated when the macrophages were exclusively treated with LPS. However, compound <jats:bold>14e<\/jats:bold> effectively suppressed the LPS\u2010induced COX\u20102 upregulation. Subsequent investigation revealed that <jats:bold>14e<\/jats:bold> is a promising compound capable of inhibiting the downstream signaling of COX\u20102. With the above interesting biological profile, molecular <jats:bold>14e<\/jats:bold> could be a promising lead to develop novel anti\u2010inflammatory agents.<\/jats:p>","DOI":"10.1002\/cbdv.202402073","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T16:10:07Z","timestamp":1729008607000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and Biological Evaluation of Isoaurone Derivatives as Anti\u2010inflammatory Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Xueqian","family":"Bai","sequence":"first","affiliation":[{"name":"Jilin Medical University  Jilin 132013 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Ye","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5353-1257","authenticated-orcid":false,"given":"Tianyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jilin Medical University  Jilin 132013 PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2014.05.004"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_56_18"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr421"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(00)00728-2"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph3072146"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)02707-9"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)00235-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0004606"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(99)02334-5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.08.048"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.02.052"},{"key":"e_1_2_9_12_1","unstructured":"L.\u2005W. 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