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The incorporation of these aza\u2010crown macrocycles significantly enhances their water solubility, positioning them as groundbreaking instances of curcumin derivatives that are fully soluble in aqueous environments. These curcumin ligands (<jats:bold>L1<\/jats:bold>, <jats:bold>L2<\/jats:bold>, and <jats:bold>L3<\/jats:bold>) were then reacted with zinc acetate to afford the coordination metal complexes (<jats:bold>L1\u2010Zn<\/jats:bold>, <jats:bold>L2\u2010Zn<\/jats:bold>, and <jats:bold>L3\u2010Zn<\/jats:bold>). Comprehensive characterization of all compounds was achieved using various analytical techniques, including 1D and 2D NMR spectroscopy, ATR\u2010FTIR spectroscopy, mass spectrometry (ESI<jats:sup>+<\/jats:sup>), elemental analysis and UV\u2010Vis spectroscopy. The <jats:italic>in\u2005vitro<\/jats:italic> cytotoxic activity of both, ligands and complexes were evaluated on three human cancer cell lines (U\u2010251, MCF\u20107, and SK\u2010LU\u20101). Compared to conventional curcumin, these compounds demonstrated improved antiproliferative potential. Additionally, a wound healing assay was conducted to assess their antimigration properties. The obtained results suggest that these modifications to the curcumin structure represent a promising approach for developing therapeutic agents with enhanced cytotoxic properties.<\/jats:p>","DOI":"10.1002\/cbdv.202402083","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T08:44:20Z","timestamp":1729500260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Water\u2010Soluble Curcumin Derivatives Including Aza\u2010Crown Ether Macrocycles as Enhancers of Their Cytotoxic Activity"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2971-0378","authenticated-orcid":false,"given":"Antonino","family":"Arenaza\u2010Corona","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico, Circuito Exterior S\/N, Ciudad Universitaria  Mexico City C.P. 04510 Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2638-0324","authenticated-orcid":false,"given":"Paola","family":"S\u00e1nchez\u2010Portillo","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Qu\u00edmicas-IICBA Universidad Aut\u00f3noma del Estado de Morelos  Av. 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