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The structures of <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> were established by analysis of spectroscopes including 1D\/2D NMR, IR, UV, and HRESIMS. Among them, the configuration of <jats:bold>1<\/jats:bold> was further confirmed by single\u2010crystal X\u2010ray diffraction. Letendrones A and B were the new phenalenyl derivatives with radical form that were firstly found in nature. In addition, bioactivity of these compounds was evaluated and compounds <jats:bold>3\u20135<\/jats:bold> exhibited inhibitory activity against LPS\u2010induced NO production in macrophages with IC<jats:sub>50<\/jats:sub> values of 4.64, 13.90, and 34.07\u2005\u03bcM. Furthermore, potential targets of the new compounds were analyzed by molecular docking in silico. As a result, compound <jats:bold>1<\/jats:bold> showed high binding with predicted 5\u2010HT<jats:sub>2c<\/jats:sub> receptor (\u25b5G=\u22128.2\u2005kcal\/mol) potentially associated with depression disease, and compound <jats:bold>2<\/jats:bold> showed significant connection with phosphodiesterase 3\u2005A (\u25b5G=\u22129.4\u2005kcal\/mol) probably against cardiovascular disorders. Our findings firstly reported the high symmetry phenalenyl compounds from natural products which would provide a basis for further development and utilization of the secondary metabolites from the endophytic fungus <jats:italic>Letendraea helminthicola<\/jats:italic> A820.<\/jats:p>","DOI":"10.1002\/cbdv.202402114","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T05:54:23Z","timestamp":1727502863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Secondary Metabolites from the Endophytic Fungus <i>Letendraea helminthicola<\/i> A820 with Anti\u2010Inflammatory Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Jianpeng","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Guangdong Pharmaceutical University  Guangzhou 510006 China"},{"name":"State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangdong Academy of Sciences  Guangzhou 510070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziling","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangdong Academy of Sciences  Guangzhou 510070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchan","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangdong Academy of Sciences  Guangzhou 510070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangdong Academy of Sciences  Guangzhou 510070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saini","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangdong Academy of Sciences  Guangzhou 510070 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Institute of Microbiology Guangdong Academy of Sciences  Guangzhou 510070 China"},{"name":"Engineering Research Center of Health Food Design &amp; 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