{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:18:25Z","timestamp":1780575505728,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T00:00:00Z","timestamp":1731024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite several studies on the <jats:italic>Satureja<\/jats:italic> L. genus, the chemical composition and biological activities of the traditional medicinal plant <jats:italic>Satureja thymbrifolia<\/jats:italic> (White Thyme), a Palestinian endemic species, are still unknown. It grows in arid regions and is used by Bedouins as a traditional medicinal herb. This study aimed to investigate <jats:italic>S. thymbrifolia<\/jats:italic> essential oils (EOs), mainly from its phytochemical pattern and biological properties. The GC\u2010MS study identified <jats:italic>p<\/jats:italic>\u2010cymene (48.53\u2009%) and thymol (23.27\u2009%) as the leading EOs components. Compared to Trolox, the EOs showed potential anti\u2010DPPH free radical activity and had broad\u2010spectrum antimicrobial potentials, with MIC values ranging from 0.13\u00b10.05 to 25\u00b10.00\u2005\u03bcL\/mL. They were most effective against <jats:italic>Candida albicans<\/jats:italic> species. The <jats:italic>S. thymbrifolia<\/jats:italic> EOs most effectively eliminated cancer cells when tested against CaCo\u20102 and HeLa cell lines (IC<jats:sub>50<\/jats:sub> values of 192.15\u00b12.47 and 194.80\u00b11.87\u2005\u03bcg\/mL, respectively). The present investigation is the first documented study of <jats:italic>S. thymbrifolia<\/jats:italic> EOs\u2019 phytochemical composition and bioactivities. The results revealed that <jats:italic>S. thymbrifolia<\/jats:italic> EOs have potential antioxidant, antimicrobial, and cytotoxic effects. These outcomes emphasized <jats:italic>S. thymbrifolia<\/jats:italic> EO's potential dietary, pharmacological, and cosmetic applications.<\/jats:p>","DOI":"10.1002\/cbdv.202402136","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T12:29:28Z","timestamp":1727785768000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Phytochemical Profiling and Bioactive Properties of Essential Oils from Endemic Palestinian <i>Satureja thymbrifolia<\/i>"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2291-6821","authenticated-orcid":false,"given":"Nidal","family":"Jaradat","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Medicine and Health Sciences An-Najah National University  Nablus 00970 Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Hawash","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Medicine and Health Sciences An-Najah National University  Nablus 00970 Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nawaf","family":"Al\u2010Maharik","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science An-Najah National University  Nablus 00970 Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Qadi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Faculty of Medicine and Health Sciences An-Najah National University  Nablus 00970 Palestine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,8]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"O.\u2005S. 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