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Hyperglycemia and oxidative stress contribute to this condition. <jats:italic>Boswellia serrata<\/jats:italic> gum resin is known for its antioxidant properties and potential in managing diabetic complications, though its nephroprotective effects are not well documented. This research aimed to determine the phytochemical constituents of <jats:italic>B. serrata<\/jats:italic> using LC\u2013MS analysis and explore its benefits in enhancing hematological markers and improving STZ\u2010induced renal dysfunction in rats. Diabetes was induced by a single dose of streptozotocin (60\u00a0mg\/kg). A total of 40 male albino Wistar rats were divided into four groups: normal control, control with <jats:italic>B. serrata<\/jats:italic> (2% w\/w), and two diabetic groups. One diabetic group served as a positive control, whereas the other received <jats:italic>B. serrata<\/jats:italic> powder (2% w\/w). Results showed that the powder reduced blood sugar, decreased renal markers, increased albumin, total protein, and restored hematological parameters. It also enhanced \u03b2\u2010cell function and prevented kidney structural abnormalities. Additionally, <jats:italic>B. serrata<\/jats:italic> reduced oxidative stress by lowering malondialdehyde and increasing glutathione, glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase, catalase, and glutathione peroxidase in renal tissues. LC\u2013MS identified 37 phenolic compounds, with apigetrin being the most abundant. These findings suggest that <jats:italic>B. serrata<\/jats:italic> holds promise for managing diabetes\u2010related kidney injury.<\/jats:p>","DOI":"10.1002\/cbdv.202402200","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T09:10:11Z","timestamp":1733735411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>Boswellia serrata<\/i> Powder Regimen Provides Significant Protection Against Renal Damage and Blood Imbalances in Diabetic Rats"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-6345","authenticated-orcid":false,"given":"Amel","family":"Kherouf","sequence":"first","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology University of Badji Mokhtar  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa","family":"Kherouf","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Molecular Biology University of Badji Mokhtar  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouassila","family":"Aouacheri","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry and Microbiology Department of Biochemistry University of Badji Mokhtar  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Doghmane","sequence":"additional","affiliation":[{"name":"Laboratory of Applied Biochemistry and Microbiology Department of Biochemistry University of Badji Mokhtar  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Saka","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Ecophysiology, Department of Biology University of Badji Mokhtar  Annaba Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eevki","family":"Adem","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science \u00c7ank\u0131r\u0131 Karatekin University  \u00c7ank\u0131r\u0131 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13040455"},{"issue":"7","key":"e_1_2_10_3_1","article-title":"An Overview of Diabetes Mellitus in Egypt and the Significance of Integrating Preventive Cardiology in Diabetes Management","volume":"14","author":"Abouzid M. 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