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Considering this species\u2019 significant essential oil content, the present study aimed to evaluate the anti\u2010edematogenic and anti\u2010inflammatory effects of the crucial oil <jats:italic>Piper tuberculatum<\/jats:italic> (EOPT) <jats:italic>in\u2005vivo<\/jats:italic>. To this end, Swiss mice (<jats:italic>Mus musculus<\/jats:italic>) of both sexes were treated orally with the EOPT at 50, 100, and 250\u2005mg\/Kg. The rotarod and open field evaluated the potential activity in the central nervous system. At the same time, formalin and abdominal writhing tests were carried out to perform the pharmacological screening of the essential oil. Next, the anti\u2010edematogenic effect was assessed using paw edema models induced by carrageenan, dextran, histamine, and arachidonic acid. The anti\u2010inflammatory activity was then characterized in peritonitis (acute) and granuloma (chronic) models. The EOPT treatment at the highest dose (250\u2005mg\/kg) showed no indication of central activity. All the EOPT doses (50, 100, and 250\u2005mg\/kg) had analgesic effects associated with anti\u2010inflammatory mechanisms in screening models. Accordingly, the treatment (EOPT 100\u2005mg\/Kg) inhibited the inflammatory process in acute and chronic models. In conclusion, EOPT has analgesic, antiedematogenic, and anti\u2010inflammatory effects, highlighting its potential use in developing anti\u2010inflammatory drugs.<\/jats:p>","DOI":"10.1002\/cbdv.202402219","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T13:25:25Z","timestamp":1731072325000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antiedematogenic and Anti\u2010Inflammatory Effects of the Essential Oil from the Fruits of <i>Piper tuberculatum<\/i> Jacq. 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