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The structures of the synthesized compounds (\n                    <jats:bold>7<\/jats:bold>\n                    \u2013\n                    <jats:bold>12<\/jats:bold>\n                    ) were elucidated by elemental analysis and FT\u2010IR, 1D (\n                    <jats:sup>1<\/jats:sup>\n                    H,\n                    <jats:sup>13<\/jats:sup>\n                    C, APT, and DEPT\u2010135), and 2D (HMQC and HMBC) NMR spectroscopies. The cytotoxic activities of the targeted compounds were determined at various concentrations against these cancer cell lines for 72\u2005h, using the MTT method. The targeted molecules (\n                    <jats:bold>7<\/jats:bold>\n                    \u2013\n                    <jats:bold>12<\/jats:bold>\n                    ) demonstrated remarkable antiproliferative activities, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 6.032\u20139.533\u2005\u03bcM against the A549\u2005cell line and 5.244\u20139.629\u2005\u03bcM against the HepG2\u2005cell line. These compounds showed activities at lower or very similar concentrations to cisplatin against the A549\u2005cell line and at much lower concentrations than cisplatin against the HepG2\u2005cell line. Among them, compounds\n                    <jats:bold>10<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    were found to be more effective against A549 and HepG2 cells, respectively, than cisplatin. These compounds were analyzed by interacting with the 1BNA, 4HJO, and 4ASD crystal structures in molecular docking studies. The docking score of 4ASD\u2010compound\n                    <jats:bold>12<\/jats:bold>\n                    interaction was calculated as \u22124.045\u2005kcal\/mol, 4HJO\u2010compound\n                    <jats:bold>10<\/jats:bold>\n                    interaction was calculated as \u22125.179\u2005kcal\/mol and 1BNA\u2010compound\n                    <jats:bold>10<\/jats:bold>\n                    interaction was calculated as \u22128.571\u2005kcal\/mol and it was determined that these compounds were theoretically better than Cisplatin. In the present study, ADME data were estimated using the web tool SwissADME. With ADME, it was calculated that the logP value of compounds\n                    <jats:bold>7<\/jats:bold>\n                    \u2013\n                    <jats:bold>12<\/jats:bold>\n                    was less than 5, the HBD number was 1, the HBA number was 7 or 8, and the molecular weight was less than 500. Properties such as the electrophilic index and chemical hardness of the designed compounds were examined by density functional theory (DFT) using B3LYP\/6\u2010311G**. In conclusion, these compounds have emerged as promising new anti\u2010cancer drug candidates.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402229","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T01:49:22Z","timestamp":1729648162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis of Sulfonamide\u2010Based Schiff Bases as Potent Anticancer Agents: Spectral Analyses, Biological Activity, Molecular Docking, ADME, DFT, and Pharmacophore Modelling Studies"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-5919","authenticated-orcid":false,"given":"Ey\u00fcp","family":"Ba\u015faran","sequence":"first","affiliation":[{"name":"Batman University, Vocational School of Technical Sciences Department of Chemistry and Chemical Processing Technologies  Batman 72060 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0401-7419","authenticated-orcid":false,"given":"Re\u015fit","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"Batman University, Vocational School of Health Services Medical Laboratory Techniques Program  Batman 72060 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5770-0847","authenticated-orcid":false,"given":"Bur\u00e7in","family":"T\u00fcrkmeno\u011flu","sequence":"additional","affiliation":[{"name":"Erzincan Binali Y\u0131ld\u0131r\u0131m University Faculty of Pharmacy Department of Analytical Chemistry  Erzincan 24002 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-9425","authenticated-orcid":false,"given":"Senem","family":"Akkoc","sequence":"additional","affiliation":[{"name":"Suleyman Demirel University Faculty of Pharmacy Department of Basic Pharmaceutical Sciences  Isparta 32260 T\u00fcrkiye"},{"name":"Bahcesehir University Faculty of Engineering and Natural Sciences  Istanbul 34353 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-6980","authenticated-orcid":false,"given":"Semiha","family":"K\u00f6pr\u00fc","sequence":"additional","affiliation":[{"name":"Erciyes University Department of Chemistry Faculty of Sciences  Kayseri 38039 T\u00fcrkiye"},{"name":"Erciyes University Technology Research and Application Center  Kayseri 38039 T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"issue":"15","key":"e_1_2_9_2_1","first-page":"17551","volume":"9","author":"Ba\u015faran E.","year":"2024","journal-title":"ACS Omega"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jccs.202100357"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2023.136225"},{"key":"e_1_2_9_5_1","unstructured":"The International Agency for Research on Cancer. 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