{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T05:04:23Z","timestamp":1781586263050,"version":"3.54.5"},"reference-count":74,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T00:00:00Z","timestamp":1738022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study was undertaken to assess the antioxidant and neuropharmacological potentials of the methanol leaf extract of\n                    <jats:italic>Acanthus ebracteatus<\/jats:italic>\n                    (MAEL) through experimental and in silico methods. The phytochemical screening (PS) and GC\u2013MS (gas chromatography\u2013mass spectrometry) identified 28 phytochemicals with different classes in nature in MAEL. The MAEL revealed better antioxidant activity through various in vitro antioxidant assays. Additionally, in the tail suspension test (TST) and forced swimming test (FST), a dose\u2010dependent reduction in immobility time was observed indicating antidepressant activity. In the elevated plus maze test (EPM), MAEL led to increased time spent and more entries in the open arms. At the same time, the hole board test (HBT) demonstrated an increase in head dipping compared to the control, both indicating anxiolytic activity. Moreover, a dose\u2010dependent reduction in locomotor activities was observed in both the open field test (OFT) and hole cross test (HCT). Molecular docking showed better binding affinities of two compounds, CID\u2010518982 and CID\u2010236641. ADME\/T analysis revealed good drug likeliness with no toxicity. Finally, the simulation demonstrated better structural stability with no significant fluctuations of the compounds with the selected receptors. In this study, compounds CID\u2010518982 and CID\u2010236641 might serve as drug candidates for treating anxiety and depression.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402250","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T12:05:06Z","timestamp":1738065906000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Comprehensive Evaluation of the Neuropharmacological Potential of Methanolic Leaf Extract of\n                    <i>Acanthus ebracteatus<\/i>\n                    (Vahl.) Using Experimental and In Silico Approaches"],"prefix":"10.1002","volume":"22","author":[{"given":"Md.","family":"Aktaruzzaman","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Biological Science and Technology Jashore University of Science and Technology  Jashore Bangladesh"},{"name":"Laboratory of Advanced Computational Neuroscience Biological Research on the Brain (BRB)  Jashore Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3266-4229","authenticated-orcid":false,"given":"Md. 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