{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:49:23Z","timestamp":1785152963354,"version":"3.55.0"},"reference-count":178,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetes is a medical condition that belongs to the group of chronic diseases that affect how the body processes glucose, the primary source of energy for cells. Glucose comes indirectly from the consumed food and is carried by bloodstream to various cells in the body. Insulin, a hormone synthesized by the pancreas plays a vital role in the conversion of glucose to energy. Managing diabetes involves regular monitoring of blood sugar levels, adopting a healthy diet, engaging in regular physical activity, and taking medications or insulin as prescribed by a healthcare provider. Proper management of diabetes may lead to the prevention or delay of diabetic complications may further sever other diseases associated impediment. Drug delivery in the management of diabetes is designed to administer insulin or other diabetes medications in a controlled and convenient manner. Recently nanotechnology has emerged as a transformative approach in the management of diabetic complications, particularly through carrier\u2010mediated nano\u2010biomedicine. Several natural products have been studied and reported for their potential role in managing diabetes. While they may not replace standard medical treatments, some of these natural products could complement existing therapies and support overall diabetes management. Therefore, this review explores the potential of nanocarriers to enhance drug delivery systems for diabetes mellitus treatment, addressing the limitations of conventional therapies that often suffer from poor bioavailability and frequent dosing requirements. Studies have demonstrated that bridging these bioactive compounds significantly enhance the therapeutic efficacy in the management of diabetes. Challenges remain in translating these technologies from laboratory settings to clinical applications; however, the potential benefits for improving glycemic control and overall quality of life for diabetic patients are substantial. Future research should focus on optimizing these nano\u2010biomedicine strategies to realize their full therapeutic potential in diabetes management.<\/jats:p>","DOI":"10.1002\/cbdv.202402258","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T11:02:50Z","timestamp":1734951770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Unlocking the Potential of Carrier Mediated Nano\u2010biomedicine in Management of Diabetes Mellitus: A\u00a0Review"],"prefix":"10.1002","volume":"22","author":[{"given":"Priya S","family":"Mistry","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Pharmacy Practice L. M. College of Pharmacy Opp. Gujarat University  Navrangpura, Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-3322","authenticated-orcid":false,"given":"Sudarshan","family":"Singh","sequence":"additional","affiliation":[{"name":"Office of Research Administration Chiang Mai University  Chiang Mai Thailand"},{"name":"Faculty of Pharmacy Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3724-0986","authenticated-orcid":false,"given":"Mehul R","family":"Chorawala","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Pharmacy Practice L. M. College of Pharmacy Opp. Gujarat University  Navrangpura, Ahmedabad Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-4541","authenticated-orcid":false,"given":"Bhupendra G","family":"Prajapati","sequence":"additional","affiliation":[{"name":"Shree S. K. Patel College of Pharmaceutical Education &amp; Research Ganpat University  Mehsana Gujarat India"},{"name":"Faculty of Pharmacy Silpakorn University  Nakhon Pathom Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devesh U","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Dr. Dayaram Patel Pharmacy College  Bardoli Gujarat India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"e_1_2_26_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajm.ajm_53_20"},{"key":"e_1_2_26_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1627_21"},{"key":"e_1_2_26_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X1604201229115531"},{"key":"e_1_2_26_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119697473.ch7"},{"key":"e_1_2_26_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020335"},{"key":"e_1_2_26_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00063.2017"},{"key":"e_1_2_26_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275"},{"key":"e_1_2_26_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0355-7"},{"key":"e_1_2_26_10_1","doi-asserted-by":"publisher","DOI":"10.4018\/IJUDH.2018070102"},{"key":"e_1_2_26_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1149239"},{"key":"e_1_2_26_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122645"},{"issue":"10","key":"e_1_2_26_13_1","first-page":"4001","volume":"129","author":"Hudish L. 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