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In this article, the extraction, analytical method, pharmacological action, and research progress of syringin\u2010containing plants were reviewed. Various extraction methods and detection methods of syringin were summarized, especially the ultrasonic\u2010assisted extraction and high\u2010performance liquid chromatography, which were recommended for the extraction and determination of syringin. We spotlighted the anti\u2010cancer, brain\u2010protective, and anti\u2010inflammatory pharmacological effects of syringin. An in\u2010depth analysis of four plants contains syringin\u2014<jats:italic>Eleutherococcus senticosus<\/jats:italic>, <jats:italic>Codonopsis pilosula<\/jats:italic>, <jats:italic>Daphne tangutica<\/jats:italic> Maxim, and <jats:italic>Syringa reticulata<\/jats:italic> subsp. <jats:italic>amurensis<\/jats:italic>. In addition, the safety and efficacy of these four plants and preparations containing syringin (Shugan Jieyu Capsule, compound Coginseng tablet, hyoscyamine ointment, and Qinfenghong Zhike capsule) were analyzed. Although syringin has been widely used in traditional medicine, its specific mechanism of action and clinical efficacy are still not completely understood, and further research is needed to explore and verify it. This study provides a valuable theoretical basis and potential research direction for the research and development of new drugs such as anti\u2010cancer and brain protection.<\/jats:p>","DOI":"10.1002\/cbdv.202402272","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T09:54:43Z","timestamp":1731923683000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Syringin: Plant Source, Traditional Uses, Anti\u2010Cancer, Brain Protection, and Related Pharmacological Properties"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4652-8949","authenticated-orcid":false,"given":"Chuan","family":"Liu","sequence":"first","affiliation":[{"name":"School of Food and Bioengineering Xihua University Chengdu P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2541-1630","authenticated-orcid":false,"given":"Huijuan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Food and Bioengineering Xihua University Chengdu P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Food and Bioengineering Xihua University Chengdu P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yafan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Food and Bioengineering Xihua University Chengdu P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangrui","family":"Yi","sequence":"additional","affiliation":[{"name":"School of Food and Bioengineering Xihua University Chengdu P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Tu","sequence":"additional","affiliation":[{"name":"Experimental Research Center China Academy of Traditional Chinese Medicine Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"12","key":"e_1_2_16_2_1","first-page":"1923","article-title":"Study on the Chemical Composition of Chuanmuxiang","volume":"39","author":"Sun Y.","year":"2019","journal-title":"Henan Traditional Chinese Medicine"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultsonch.2022.106039"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2022.115813"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms13067607"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23049"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.12.002"},{"issue":"12","key":"e_1_2_16_8_1","first-page":"2275","article-title":"Regulation of Syringin, Chlorogenic acid and 1,5\u2010Dicaffeoylquinic Acid Biosynthesis in Cell Suspension Cultures of Saussurea involucrata]","volume":"39","author":"Chen R.\u2010D.","year":"2014","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-006-9035-5"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1801300403"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-2003-9-1019"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00299-005-0953-9"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08475"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700099"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45070376"},{"key":"e_1_2_16_16_1","first-page":"1","article-title":"Screening of Neuraminidase Inhibitors From the Leaves of Syringa velutina Kom. via Compound Fractionation and In Vitro Activity Evaluation","volume":"4","author":"Zhang Y.","year":"2016","journal-title":"Analytical Methods"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1100600602"},{"issue":"03","key":"e_1_2_16_18_1","first-page":"28","article-title":"Content Determination of Syringin in Lilac Leaves By HPLC China Licensed Pharmaist","volume":"12","author":"Zhang C. 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