{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:49:02Z","timestamp":1773013742081,"version":"3.50.1"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Oxidative stress is a pivotal factor in the pathogenesis of malaria, contributing to the development of conditions such as anemia, respiratory complications, and cerebral malaria. To counteract oxidative damage, we evaluated the effects of vitamin E (\u03b1\u2010TOH) and\n                    <jats:sc>d<\/jats:sc>\n                    \u2010\u03b1\u2010tocopherol polyethylene glycol 1000 succinate (TPGS) supplementation on parasitemia progression, mortality rate, and blood\u2010brain barrier (BBB) permeability in\n                    <jats:italic>Plasmodium berghei<\/jats:italic>\n                    ANKA\u2010infected mice. The mice were divided into four groups: a control group (untreated and uninfected), an infected group (Pb), a TPGS\u00a0+\u00a0Pb group, and an \u03b1\u2010TOH\u00a0+\u00a0Pb group. The results demonstrated that TPGS was more effective than \u03b1\u2010TOH, exhibiting a lower parasitemia (9.59%) and mortality (40%) by Day 12 and superior BBB protection in advanced infection stages. These findings suggest that TPGS may represent a promising therapeutic strategy for the management of malaria. Molecular docking analysis indicated that TPGS exhibited the highest binding affinity with plasmepsin 2 (\u22127.3\u00a0kcal\/mol), whereas vitamin E demonstrated the strongest binding with plasmepsin 1 (\u22127.2\u00a0kcal\/mol).\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402297","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T16:08:48Z","timestamp":1734451728000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating the Antimalarial Potential of\n                    <scp>d<\/scp>\n                    \u2010\u03b1\u2010Tocopherol Polyethylene Glycol 1000 Succinate and \u03b1\u2010Tocopherol, In Vivo Studies in\n                    <i>Plasmodium berghei<\/i>\n                    \u2010Infected Mice and Molecular Docking Insights"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7175-2731","authenticated-orcid":false,"given":"Mariana","family":"dos Santos Guimar\u00e3es","sequence":"first","affiliation":[{"name":"Oxidative Stress Research Laboratory, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-3791","authenticated-orcid":false,"given":"Everton Luiz Pompeu","family":"Varela","sequence":"additional","affiliation":[{"name":"Oxidative Stress Research Laboratory, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Postgraduate Program in Biodiversity and Biotechnology\u2013BIONORTE Network Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4700-7942","authenticated-orcid":false,"given":"Ant\u00f4nio Rafael","family":"Quadros Gomes","sequence":"additional","affiliation":[{"name":"Oxidative Stress Research Laboratory, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1454-9638","authenticated-orcid":false,"given":"Eliete Pereira","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Oxidative Stress Research Laboratory, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Postgraduate Program in Biodiversity and Biotechnology\u2013BIONORTE Network Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7881-8625","authenticated-orcid":false,"given":"Oberdan Oliveira","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Adolpho Ducke Laboratory, Botany Coordination Museu Paraense Em\u00edlio Goeldi  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabrouk","family":"Horchani","sequence":"additional","affiliation":[{"name":"Faculty of Sciences of Monastir, Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity Medicinal Chemistry and Natural Products (LR11ES39), University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayet","family":"Edziri","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Laboratory of Transmissible Diseases and Biologically Active Substances University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0640-7496","authenticated-orcid":false,"given":"Eloisa Helena de Aguiar","family":"Andrade","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biodiversity and Biotechnology\u2013BIONORTE Network Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Adolpho Ducke Laboratory, Botany Coordination Museu Paraense Em\u00edlio Goeldi  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4076-2443","authenticated-orcid":false,"given":"Mozaniel Santana","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Adolpho Ducke Laboratory, Botany Coordination Museu Paraense Em\u00edlio Goeldi  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9528-0361","authenticated-orcid":false,"given":"Sandro","family":"Perc\u00e1rio","sequence":"additional","affiliation":[{"name":"Oxidative Stress Research Laboratory, Institute of Biological Sciences Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Postgraduate Program in Biodiversity and Biotechnology\u2013BIONORTE Network Federal University of Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/2317\u20101782\/20212021076"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4RA13315C"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30324-6"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2020.1807940"},{"key":"e_1_2_10_6_1","unstructured":"Geneva World Health Organization \u201cWorld Malaria Report 2023 \u201d (2023) https:\/\/www.who.int\/publications\/i\/item\/9789240086173."},{"key":"e_1_2_10_7_1","article-title":"Dia da malaria nas Americas \u2010 um panorama da malaria no Brasil em 2022 e no primeiro semestre de 2023","volume":"55","author":"Minist\u00e9rio da Sa\u00fade (MS), Secr. Vigil\u00e2ncia em Sa\u00fade e Ambient, Brasil","year":"2024","journal-title":"Boletim Epidemiologico"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201809903"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.04.033"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac234"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.12.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.768182"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115949"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0717-0"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1474169"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-015-4722-6"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-0900"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025767"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26489"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M085043"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.07.018"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22711"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.01.014"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201700623"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13071016"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.02.006"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.120045"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081492"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2020.104946"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01336"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01622"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfae086"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14121285"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-018-6016-2"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50884-9"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-021-02047-1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-014-0086-0"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.863568"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.968325"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.11.010"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00743\u201021"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2019.04.010"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114461"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43162\u2010020\u201000024\u2010x"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms131216346"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14245303"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030722"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpim.83"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3791\/50062"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001052"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2019.108349"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1575-4"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2016.00139"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3429-5_14"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475\u20102840\u20106\u20108"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2008"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.01.009"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010064"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3072"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2003.11.003"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.777400"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.541624"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2011.04.009"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444902014695"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402297","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202402297","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:34:04Z","timestamp":1773009244000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,31]]},"references-count":64,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cbdv.202402297"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402297","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,31]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402297"}}