{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T22:37:22Z","timestamp":1793140642472,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Blanchetia heterotricha<\/jats:italic>\n                    is a species popularly used for its medicinal properties. However, few scientific records report the investigation of its chemical composition and biological activity. Herein, a metabolomics and multivariate statistical analysis approach was used to assess the chemical composition, antioxidant, and antimicrobial activity of\n                    <jats:italic>B. heterotricha<\/jats:italic>\n                    essential oil (BHEO) and fixed extracts (nonvolatile). Thirty\u2010six metabolites were identified in the essential oil by gas chromatography\u2013mass spectrometry (GC\u2013MS), whereas 59 metabolites were identified in the fixed extracts by high\u2010performance liquid chromatography coupled with high\u2010resolution mass spectrometry (HPLC\u2013HRMS). The essential oil and fixed extracts showed varying degrees of antioxidant and antimicrobial activities. The antioxidant activity varied from 7.27\u00a0\u00b1\u00a00.95\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for the root methanolic extract to 513.25\u00a0\u00b1\u00a07.77\u00a0\u00b5g\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    for the seed hexane extract. Extracts obtained with ethyl acetate showed the most promising antimicrobial activity, followed by extracts obtained with methanol and hexane. Multivariate statistical analysis allowed the identification of possible contributors to the observed activities within the extracts. This is the first study to assess the antimicrobial activity in any\n                    <jats:italic>Blanchetia<\/jats:italic>\n                    species. The combination of metabolomics and multivariate statistical analysis was a powerful tool to identify bioactive compounds, highlighting the potential of BHEO and fixed extracts as sources of metabolites with antioxidant and antimicrobial properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402311","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T10:49:36Z","timestamp":1734950976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["GC\u2013MS and HPLC\u2013HRMS Metabolite Profiling and Biological Activities of\n                    <i>Blanchetia heterotricha<\/i>\n                    Extracts"],"prefix":"10.1002","volume":"22","author":[{"given":"Victor S. A.","family":"de Lira","sequence":"first","affiliation":[{"name":"Metabolomics Research Group, Instituto de Qu\u00edmica Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floric\u00e9a M.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Metabolomics Research Group, Instituto de Qu\u00edmica Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo N.","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Exatas e da Terra I Universidade do Estado da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes C.","family":"Souza\u2010Neta","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Exatas e da Terra I Universidade do Estado da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Zambotti\u2010Villela","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pio","family":"Colepicolo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Qu\u00edmica Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidyanne Y. S.","family":"Aona","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Agr\u00e1rias, Ambientais e Biol\u00f3gicas Federal University of Rec\u00f4ncavo da Bahia  Cruz das Almas Bahia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-5076","authenticated-orcid":false,"given":"Paulo R.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Metabolomics Research Group, Instituto de Qu\u00edmica Universidade Federal da Bahia Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114165"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112547"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/1519-6984.237642"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0187599"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1600\/036364415X686585"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/BT13301"},{"key":"e_1_2_10_8_1","article-title":"Essential Oils' Chemical Characterization and Investigation of Some Biological Activities: A Critical Review","volume":"3","author":"Dhifi W.","year":"2016","journal-title":"Medicines (Basel)"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2022.2074556"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2020.112552"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2023.2165169"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/app9245420"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109429"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-9490-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-017-8822-y"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2024.2338174"},{"key":"e_1_2_10_17_1","article-title":"Chemical Composition and Antifungal Activity of Myrcia multiflora and Eugenia florida Essential Oils","volume":"26","author":"Ferreira O. 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