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With rising resistance to antifungal treatments, understanding and controlling this opportunistic fungus has never been more crucial. This study highlights the potential of combining natural plant extracts, specifically the aqueous (<jats:italic>Jd<\/jats:italic>ext<jats:sub>Aq<\/jats:sub>) and ethanolic (<jats:italic>Jd<\/jats:italic>ext<jats:sub>Et<\/jats:sub>) extracts of <jats:italic>Jatropha dioica<\/jats:italic>, with nanotechnology in the form of magnetite nanoparticles (MNPs) to combat this persistent pathogen. FTIR spectra revealed significant interactions between the metabolites and MNPs, specifically through binding to the Fe<jats:sup>3+<\/jats:sup> and Fe<jats:sup>2+<\/jats:sup> sites. The average size of the MNPs was 11\u00b13\u2005nm, and they are non\u2010toxic even at high concentration (500\u2005\u03bcg\/ml). The same effect is observed with <jats:italic>Jd<\/jats:italic>ext<jats:sub>Et<\/jats:sub>; however, <jats:italic>Jd<\/jats:italic>ext<jats:sub>Aq<\/jats:sub> is cytotoxic at this concentration. The <jats:italic>Jd<\/jats:italic>ext<jats:sub>Aq<\/jats:sub>\u2010MNPs hybrid is toxic even at very low concentrations (250\u201350\u2005\u03bcg\/ml). All materials demonstrated high inhibition against <jats:italic>C. albicans<\/jats:italic>. At safe concentrations for cell viability, MNPs (500\u2005\u03bcg\/ml) and <jats:italic>Jd<\/jats:italic>ext<jats:sub>Et<\/jats:sub>\u2010MNPs (500\u201350\u2005\u03bcg\/ml) achieved the highest inhibition rates of 97.13\u2009% and 97.56\u2009%, respectively. As antifungal resistance rises, these findings pave the way for innovative therapeutic strategies against this opportunistic pathogen.<\/jats:p>","DOI":"10.1002\/cbdv.202402339","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T13:12:04Z","timestamp":1731417124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Invasive Candidiasis: A Promising Approach Using <i>Jatropha Dioica<\/i> Extracts and Nanotechnology"],"prefix":"10.1002","volume":"22","author":[{"given":"Carlos","family":"Fern\u00e1ndez\u2010Villascan","sequence":"first","affiliation":[{"name":"Departamento de Ingenier\u00eda Qu\u00edmica Instituto Tecnol\u00f3gico de Celaya Tecnol\u00f3gico Nacional de M\u00e9xico  Av. 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