{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T13:18:06Z","timestamp":1787404686941,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:00:00Z","timestamp":1736035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study highlights the prooxidant, antiproliferative and anti\u2010inflammatory potential of ripe\n                    <jats:italic>Meyna spinosa<\/jats:italic>\n                    Roxb. Ex Link fruit extracts. Chemical analysis by high\u2010resolution mass spectrometry and AAS identified compounds like ursolic acid, oleanolic acid, lupeol, betulin, scopoletin, phloroglucinol and secoxyloganin and micro\u2010elements like iron, copper, zinc and manganese. Antioxidant assays (DPPH, FRAP, metal chelation, reaction oxygen species) revealed that the\n                    <jats:italic>M. spinosa<\/jats:italic>\n                    ethyl acetate extract (MSEA) had higher phenolic (37.83\u00a0mg GAE\/g DW) and flavonoid (60.22\u00a0mg QE\/g DW) content, showing strong antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    of 7.5\u00a0\u00b5g\/mL), while the\n                    <jats:italic>M. spinosa<\/jats:italic>\n                    methanolic extract (MSM) exhibited higher FRAP activity (39.666\u00a0\u00b5g AAE\/g DW). Prooxidant activity was demonstrated through Trolox and NADH oxidation. Both extracts exhibited antiproliferative effects in A549 and MCF7 cancer cells with an increase in concentration and time. Anti\u2010inflammatory effects were observed by reductions in nitric oxide, COX\u20102, IL\u20106 and TNF\u2010\u03b1 levels in lipopolysaccharides\u2010stimulated RAW 264.7 and THP\u20101 cells. Nitrite levels reduced from 23.778 to 5.222\u00a0\u00b5M, COX\u20102 levels from 51.136 to 9.581\u00a0\u00b5g\/mL, IL\u20106 levels from 62.728\u00a0ng\/mL to 13.463\u00a0pg\/mL and TNF\u2010\u03b1 level from 474.890 to 143.115\u00a0pg\/mL. In vivo, MSEA reduced carrageenan\u2010induced paw oedema by 23.45%.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402342","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:38:46Z","timestamp":1734957526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Phytochemical Characterization, Prooxidant, Antiproliferative and Anti\u2010Inflammatory Potential of\n                    <i>Meyna spinosa<\/i>\n                    Roxb. Ex Link Ripe Fruit"],"prefix":"10.1002","volume":"22","author":[{"given":"Jyoti Lakshmi Hati","family":"Boruah","sequence":"first","affiliation":[{"name":"Biotechnology Group, Biological Sciences and Technology Division CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moloya","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanlalhruaii","family":"Famhawite","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dipankar","family":"Barman","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deep Jyoti","family":"Das","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Nusalu","family":"Puro","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Biswas","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prosenjit","family":"Mridha","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parishmita","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Biotechnology Group, Biological Sciences and Technology Division CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Gajbhiye","sequence":"additional","affiliation":[{"name":"Central Instrument Division National Institute of Pharmaceutical Education and Research Hajipur Bihar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9328-4211","authenticated-orcid":false,"given":"Rinku","family":"Baishya","sequence":"additional","affiliation":[{"name":"Centre for Pre\u2010clinical Studies CSIR\u2010North East Institute of Science and Technology (NEIST) Jorhat Assam India"},{"name":"AcSIR\u2014Academy of Scientific and Innovative Research Ghaziabad Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15128602"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/15538362.2018.1444532"},{"key":"e_1_2_10_4_1","first-page":"6","article-title":"Protective Impact of Fruits and Vegetable Intake on cardiovascular Risk Factors\u2014A Review","volume":"13","author":"Kaur H.","year":"2019","journal-title":"Journal of Clinical and Diagnostic Research"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods9101474"},{"key":"e_1_2_10_6_1","first-page":"365","article-title":"Evaluation of Phytochemicals, Antioxidant Activity and Elemental Content of Adiantum capillus veneris Leaves","volume":"4","author":"Rajurkar N. 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