{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:08:52Z","timestamp":1781014132064,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Malaria is an infectious disease, endemic to tropical and sub\u2010tropical regions causing half a million people's deaths every year. Bioactive compounds derived from medicinal plants are used to treat malaria disease and its complications. <jats:italic>H. cannabinus<\/jats:italic> and <jats:italic>C. capsularis<\/jats:italic> are two edible medicinal plants widely cultivated throughout the state of Assam in India. In this study, in\u2010vitro and in\u2010silico investigations were performed to explore the anti\u2010malarial activity of the plant extracts against <jats:italic>Plasmodium falciparum<\/jats:italic> with its validation of hemocompatibility on human RBC. We report <jats:italic>H. cannabinus<\/jats:italic> and <jats:italic>C. capsularis<\/jats:italic> extracts possess highly potent antimalarial activity against <jats:italic>Plasmodium falciparum<\/jats:italic> with IC<jats:sub>50<\/jats:sub> values of 3.80 \u00b1\u00a00.3 and 7.90 \u00b1\u00a00.8 \u00b5g\/mL, respectively. The plant extracts showed growth inhibition of A549 lung adenocarcinoma cells, no toxicity on non\u2010cancerous Vero cells, and no hemolytic activity on human RBCs. The GC\u2010MS analysis detected bioactive compounds 2\u2010pyrazoline\u20103\u2010carboxylic acid; 5\u2010hydroxy\u20101\u2010(4\u2010methyl benzoyl)\u20105\u2010phen 5\u2010oxo\u20101\u2010phenyl\u20104H\u2010pyrazole\u20103\u2010carboxylic acid; 9\u2010oximino\u20102,7\u2010diethoxyfluorene; and nonane\u2010diamide, n, n'\u2010di\u2010benzoyloxy in <jats:italic>H. cannabinus<\/jats:italic>; and, (+)\u2010sesamin; tetrahydropyran\u20104\u2010carboxylic acid, 4\u2010phenyl\u2010, (3\u2010chloro\u20104\u2010methylphenyl; and safrole in <jats:italic>C. capsularis<\/jats:italic>. In in\u2010silico study, antimalarial compounds in the extracts were predicted to have good binding affinities with docking score of &lt;\u22127.5\u00a0kcal\/mol on Falcipain\u20102, and Cytchrome c2 proteins that promotes the\u00a0growth and invasion of <jats:italic>P. falciparum<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cbdv.202402366","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T10:59:01Z","timestamp":1732100341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring Antimalarial and Cytotoxic Activities of <i>Hibiscus cannabinus<\/i> and <i>Corchorus capsularis<\/i> Extracts Through In\u2010Vitro and In\u2010Silico Approaches"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-0241","authenticated-orcid":false,"given":"Mettle","family":"Brahma","sequence":"first","affiliation":[{"name":"Department of Biochemistry Central University of Haryana  Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prajjalendra","family":"Barooah","sequence":"additional","affiliation":[{"name":"Guwahati Biotech Park Science Technology and Climate Change Department Government of Assam  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-8825","authenticated-orcid":false,"given":"Mulaka","family":"Maruthi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Central University of Haryana  Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,5]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"World Malaria Report 2022","author":"W. 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