{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:23:37Z","timestamp":1778775817660,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Baccaurea motleyana<\/jats:italic>\n                    M\u00fcll. Arg. (Rambai), an Asian fruit belonging to the Phyllanthaceae family, is cultivated throughout Southeast Asia and has been traditionally utilized in folk medicine to address eye discomfort, digestive issues, insomnia, and fevers. This study of the peel employed four Kupchan fractions (PSF, DSF, ESF, and ASF) obtained from the methanol extract of the peel of\n                    <jats:italic>B. motleyana<\/jats:italic>\n                    for in vitro assessments, including antioxidant cytotoxicity and antimicrobial activities. The crude methanol extract was also used for in vivo evaluations, focusing on antidiarrheal and antidepressant effects, complemented by phytochemical screening and analysis using GC\u2013MS\/MS. The investigation of\n                    <jats:italic>B. motleyana<\/jats:italic>\n                    methanol peel extract identified 20 phytochemicals, with primary constituents, including phenol, 3,5\u2010bis(1,1\u2010dimethylethyl) (26.14%) and 1\u2010heptadec\u20101\u2010ynyl\u2010cyclohexanol (23.12%). The extract exhibited potent antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    : 9.43\u00a0\u00b5g\/mL) and cytotoxicity (LC\n                    <jats:sub>50<\/jats:sub>\n                    : 6.01\u00a0\u00b5g\/mL). The most significant antidiarrheal effect was observed at a dosage of 400\u00a0mg\/kg. Molecular docking studies revealed that compounds, such as C9, C2, and C19, displayed noteworthy binding affinities against glutathione reductase (\u22126.3\u00a0kcal\/mol), urease oxidase (\u22126\u00a0kcal\/mol), and monoamine oxidase A (\u22126.5\u00a0kcal\/mol) receptors. In summary, our study demonstrates that fruits, like Rambai, could serve as a promising source for therapeutics and drug development in Asian countries.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402444","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T22:36:44Z","timestamp":1733956604000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Miraculous Asian Fruit\n                    <i>Baccaurea motleyana<\/i>\n                    M\u00fcll. Arg. (Rambai): Exploring the Phyto\u2010Pharmacological Potentials of Fruit Peel Through GC\u2013MS\/MS, In Vitro, In Vivo, and In Silico Approaches"],"prefix":"10.1002","volume":"22","author":[{"given":"Saima Jahan","family":"Riti","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences State University of Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1930-7890","authenticated-orcid":false,"given":"Suriya Akter","family":"Shompa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences State University of Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5319-1398","authenticated-orcid":false,"given":"Hasin","family":"Hasnat","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences State University of Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md. Mirazul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences State University of Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2278","authenticated-orcid":false,"given":"Safaet","family":"Alam","sequence":"additional","affiliation":[{"name":"Chemical Research Division, BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences State University of Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanoy","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Pharmaceutical Sciences State University of Bangladesh  Dhaka Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlai","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital  Lishui Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuxiao","family":"Shao","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital  Lishui Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanghu","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital  Lishui Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiwu","family":"Geng","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital  Lishui Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-3925","authenticated-orcid":false,"given":"Abdullah Al","family":"Mamun","sequence":"additional","affiliation":[{"name":"Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's Hospital  Lishui Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"16","article-title":"Nutritional and Medicinal Value of Underutilized Fruits","volume":"3","author":"Pal R.","year":"2019","journal-title":"Acta Scientific Agriculture"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7591951"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2012.0275"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1428341"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050559"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15373\/2249555X\/DEC2013\/14"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v24i2.54716"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v25i1.57837"},{"issue":"1","key":"e_1_2_10_10_1","first-page":"3","article-title":"Indian Herbal Drug for General Healthcare: An Overview","volume":"6","author":"Pandey M. M.","year":"2008","journal-title":"Internet Journal of Alternative Medicine"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjac.2023.100336"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v26i2.67808"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1347069"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e27533"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/9781685858117"},{"key":"e_1_2_10_16_1","volume-title":"Edible Medicinal and Non\u2010Medicinal Plants","author":"Lim T. K.","year":"2012"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/09735070.2011.11886406"},{"issue":"11","key":"e_1_2_10_18_1","first-page":"361","article-title":"Medicinal Uses of Plants by a Female Folk Medicinal Practitioner of Narayanganj District, Bangladesh","volume":"4","author":"Alam M. S.","year":"2015","journal-title":"World Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.06.001"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190215121712"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1101\/2020.05.18.101113"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2020.11.004"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1359815"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27113474"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.671498"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2020.01.005"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-020-00528-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043266"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijpb13010003"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v22i2.42307"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-177-2_19"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e28460"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00054a013"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2020.105258"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.100970"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2004.02.025"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.01.074"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1099-1573(200006)14:4<250::AID-PTR587>3.0.CO;2-J"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.35.2.116.13282"},{"issue":"12","key":"e_1_2_10_40_1","first-page":"370","article-title":"Bioactivity of Crude Extracts of Euphorbia kamerunica Pax Using Brine Shrimp (Artemia salina) Lethality Assay","volume":"2","author":"Ogunnusi T. A.","year":"2008","journal-title":"Journal of Medicinal Plants Research"},{"key":"e_1_2_10_41_1","first-page":"149","article-title":"Antibiotic Susceptibility Testing by a Standardized Single Disc Method","volume":"45","author":"Bauer A. W.","year":"1996","journal-title":"American Journal of Clinical Pathology"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.5455\/jabet.2020.d127"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00379-2"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3329\/bpj.v26i2.67807"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-92176-1"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-25"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-021-03165-5"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.202100061"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-021-02701-0"},{"issue":"3","key":"e_1_2_10_50_1","first-page":"369","article-title":"Antimicrobial Activity and Spectral Chemical Analysis of Methanolic Leaves Extract of Adiantum capillus\u2010veneris Using GC\u2010MS and FT\u2010IR Spectroscopy","volume":"8","author":"Hadi I.","year":"2016","journal-title":"International Journal of Pharmacognosy and Phytochemical Research"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/bio.867"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3329\/jujbs.v3i1.28276"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-13-164"},{"issue":"1","key":"e_1_2_10_54_1","first-page":"72","article-title":"Antimicrobial Activity of Natural Products From Medicinal Plants","volume":"7","author":"Sher A.","year":"2009","journal-title":"Global Journal of Medical Students"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.01.044"},{"key":"e_1_2_10_56_1","first-page":"2","article-title":"Measurement of Glutathione Reductase Activity","volume":"1","author":"Mannervik B.","year":"1999","journal-title":"Current Protocols in Toxicology"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.05.043"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112268"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.4172\/2329-6917.1000209"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1088\/1755-1315\/1041\/1\/012075"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00231-3"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.08.008"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202401268"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26030708"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e08475"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz424"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2965"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202402444","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:34:24Z","timestamp":1773009264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cbdv.202402444"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402444","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"2024-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402444"}}