{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T09:35:18Z","timestamp":1770284118945,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>In searching for novel insecticide lead, 20 new <jats:italic>meta<\/jats:italic>\u2010diamide compounds containing triazole were designed and synthesized regarding cyproflanilide as lead compound. All the compounds were characterized by <jats:sup>1<\/jats:sup>H NMR, <jats:sup>13<\/jats:sup>C NMR, and High\u2010resolution mass spectra (HR MS). In preliminary bioassay, we found that one of the compounds: <jats:italic>N<\/jats:italic>\u2010(cyclopropylmethyl)\u2010<jats:italic>N<\/jats:italic>\u2010(5\u2010((2,6\u2010dibromo\u20104\u2010(1,2,2,2\u2010tetrafluoro\u20101\u2010(trifluoromethyl)ethyl)phenyl)carbamoyl)\u20102\u2010(1<jats:italic>H<\/jats:italic>\u20101,2,4\u2010triazol\u20101\u2010yl)phenyl)\u20106\u2010(trifluoromethyl) nicotinamide (<jats:bold>16a<\/jats:bold>) had high activity against the target organism <jats:italic>Plutella xylostella<\/jats:italic> at 1\u00a0mg\/L and against the target organism <jats:italic>Mythimna separata<\/jats:italic> at 2\u00a0mg\/L. It is obviously superior to the known compounds <jats:bold>I<jats:sub>a<\/jats:sub><\/jats:bold> and <jats:bold>I<jats:sub>b<\/jats:sub><\/jats:bold>, and it is equivalent to cyproflanilide, and the LC<jats:sub>50<\/jats:sub> values of the compound against <jats:italic>P. xylostella<\/jats:italic> and <jats:italic>M. separata<\/jats:italic> were 0.90\u00a0mg\/L and 0.64\u00a0mg\/L, respectively. It is providing important clues for subsequent structure\u2013activity relationship (SAR) studies. From this, we explored the SAR of these compounds. Through comprehensive analysis of their structural characteristics and insecticidal activity data, we found that different halogen substituents on benzene ring and different aromatic substituents on amino group in the compound had significant effects on insecticidal activity. This has certain guiding significance for further structural optimization and activity enhancement.<\/jats:p>","DOI":"10.1002\/cbdv.202402460","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T14:19:21Z","timestamp":1733235561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel <i>Meta<\/i>\u2010Diamide Derivatives Bearing Triazole: Design, Synthesis, and Bioactivity"],"prefix":"10.1002","volume":"22","author":[{"given":"Chengyi","family":"Yan","sequence":"first","affiliation":[{"name":"School of Chemistry and Chemical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyong","family":"Liu","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co. Ltd  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juncheng","family":"Xiang","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co. Ltd  Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0960-3302","authenticated-orcid":false,"given":"Daoxin","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Changsha University of Science and Technology  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minhua","family":"Liu","sequence":"additional","affiliation":[{"name":"CAC Nantong Chemical Co. 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