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Plants from the genus\n                    <jats:italic>Goniothalamus<\/jats:italic>\n                    , belonging to the Annonaceae family, have garnered significant interest as potential sources of active lead compounds. Over the last five decades, researchers have isolated 357 compounds from\n                    <jats:italic>Goniothalamus<\/jats:italic>\n                    species (GCs), which exhibit a wide range of pharmacological properties, including cytotoxicity, antibacterial, antifungal, antiplasmodial, antioxidant, and other activities. Notably, cytotoxicity stands out as the most prominent characteristic of GCs. This review also summarizes the structure\u2013activity relationship (SAR) studies related to the cytotoxicity of GCs and their underlying mechanisms. In summary, our objective is to provide an overview of the research progress concerning the\n                    <jats:italic>Goniothalamus<\/jats:italic>\n                    genus, aiming to foster further development and utilization of these plants.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402461","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T10:20:36Z","timestamp":1737109236000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Comprehensive Review of Phytochemistry and Anticancer of the Genus\n                    <i>Goniothalamus<\/i>"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1693-5873","authenticated-orcid":false,"given":"Fan","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pharmacy Shanghai Pudong New Area Gongli Hospital  Shanghai P. R. 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