{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:00:48Z","timestamp":1771484448393,"version":"3.50.1"},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The fruit and other parts of <jats:italic>Momordica cymbalaria<\/jats:italic> are known to have medicinal properties. The study investigates the chemical composition and functional groups of <jats:italic>M. cymbalaria<\/jats:italic> fruits to assess the insecticidal potential of its bioactive metabolites. In silico approach was used to understand the mechanism behind the insecticidal nature of these metabolites. Ethyl acetate extract has 18 compounds, whereas 20 compounds were identified in methanol using gas chromatography\u2013mass spectroscopy analysis. The extracts contain several functional groups, including alkanes, esters, carboxylic acids, amides and aromatic groups. The insecticidal bioassay using methanol and ethyl acetate extracts of <jats:italic>M. cymbalaria<\/jats:italic> on <jats:italic>Aedes aegypti<\/jats:italic> and <jats:italic>Culex quinquefasciatus<\/jats:italic> mosquito larvae shows that the LC<jats:sub>50<\/jats:sub> value for <jats:italic>A. aegypti<\/jats:italic> was 65.7\u00a0ppm, for <jats:italic>C. quinquefasciatus<\/jats:italic> was 96.9\u00a0ppm and for ethyl acetate and methanol extract is 282.36 and 388.09\u00a0ppm. Molecular docking of secondary metabolites was performed with five insect proteins, namely, odorant binding protein (OBP), cytochrome P450 (CYP450), prophenol oxidase (PPO), arylalkylamine <jats:italic>n<\/jats:italic>\u2010acetyltransferease (aaNAT) and sterol carrier protein (SCP). Results show that methyl 6\u2010<jats:italic>cis<\/jats:italic>, 9\u2010<jats:italic>cis<\/jats:italic>, 11\u2010<jats:italic>trans<\/jats:italic>\u2010octadecatrienoate has high binding affinity with sterol carrier protein (SCP\u20102) besides showing binding with other insect proteins. The data suggest that methyl 6\u2010<jats:italic>cis<\/jats:italic>, 9\u2010<jats:italic>cis<\/jats:italic>, 11\u2010<jats:italic>trans<\/jats:italic>\u2010octadecatrienoate has multiple insecticidal actions and may serve as a green insecticide.<\/jats:p>","DOI":"10.1002\/cbdv.202402475","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T11:11:31Z","timestamp":1733224291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Insecticidal Activity of Fatty Acids From the Fruit Extract of <i>Momordica cymbalaria<\/i> Fenzl Ex Naudin, Has Insecticidal Activities on Mosquito Larvae"],"prefix":"10.1002","volume":"22","author":[{"given":"Subramanian","family":"Monika","sequence":"first","affiliation":[{"name":"Department of Biotechnology Periyar University  Salem Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathiazhakan","family":"Lavanya","sequence":"additional","affiliation":[{"name":"Department of Botany Periyar University  Salem Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veeran","family":"Sethuraman","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Periyar University  Salem Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murugan","family":"Arunthirumeni","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Periyar University  Salem Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuppusamy","family":"Selvam","sequence":"additional","affiliation":[{"name":"Department of Botany Periyar University  Salem Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1910-5510","authenticated-orcid":false,"given":"Muthugounder Subramanian","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Periyar University  Salem Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects14030221"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003545"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13337\u2010016\u20100307\u2010y"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/insects13100962"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010935"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2021.101471"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13399\u2010023\u201004967\u20103"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1519\u20106984.236498"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijpb13010003"},{"key":"e_1_2_10_11_1","unstructured":"A. B.Siddique M. A. A.Bachchu M. N.Uddin M. A. A.Nomun andM. S.Rana \u201cRepellent and Insecticidal Efficacy of Some Botanical Extracts AgainstBactrocera cucurbitae(Coquillett) (Diptera:Tephritidae) \u201d7 no.3(2019):124\u2013129."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fagro.2021.676208"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2023.2170317"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2020.04.025"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112186"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781032697598-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cropro.2018.02.014"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2017.05.004"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27520"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2023.105489"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180208"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01163"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043170"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1128577"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026618666181025111605"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915\u2010015\u20100225\u20102"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112186"},{"issue":"1","key":"e_1_2_10_28_1","first-page":"107","article-title":"In Vitro Antioxidant Studies of Momordica cymbalaria","volume":"8","author":"Prashanth S. J.","year":"2013","journal-title":"Asian Journal of Bio Science"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.16928"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975\u20108232.9(2).432\u201041"},{"issue":"1","key":"e_1_2_10_31_1","first-page":"28","article-title":"An Updated Pharmacological Overview on Momordica cymbalaria (Athalakkai)","volume":"5","author":"Gopalasatheeskumar K.","year":"2018","journal-title":"Innoriginal: International Journal of Sciences"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10722\u2010022\u201001494\u20104"},{"key":"e_1_2_10_33_1","unstructured":"E.Keshamma \u201cEvaluation of In\u2010Vitro Antidiabetic Activities of Fruit Extracts ofMomordica cymbalaria \u201dInternational Journal for Recent Developments in Science and Technology1 no.6(2009):67\u201379."},{"issue":"4","key":"e_1_2_10_34_1","first-page":"146","article-title":"In Vitro Antimicrobial Activity of Leaf, Stem Fruit and Root Crude Extracts of Momordica cymbalaria Fenzl: A Medicinally Important Cucurbit","volume":"10","author":"Chaitanya G.","year":"2021","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_10_35_1","first-page":"33","volume-title":"Recent Researches in Social Science","author":"Mahendhiran M.","year":"2020"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.20546\/ijcmas.2017.604.279"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.22271\/plants.2021.v9.i3c.1289"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.15835\/nsb939910"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.26452\/ijrps.v11i1.1963"},{"issue":"7","key":"e_1_2_10_40_1","first-page":"108","article-title":"In\u2010Vitro Conservation of Momordica cymbalaria Hook. F","volume":"7","author":"Madhale S. V.","year":"2018","journal-title":"World Journal of Pharmaceutical Research"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.22361"},{"issue":"1","key":"e_1_2_10_42_1","first-page":"1","article-title":"Mosquitocidal and Repellent Activity of the Leaf Extract of Citrullus Vulgaris (Cucurbitaceae) Against the Malarial Vector, Anopheles stephensi Liston (diptera culicidae)","volume":"12","author":"Mullai K.","year":"2008","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.22271\/23487941.2022.v9.i4a.617"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2017.07.007"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25153484"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.4236\/ae.2023.112005"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094\u2010020\u201000100\u20107"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2016.08.015"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb45060316"},{"issue":"2","key":"e_1_2_10_50_1","first-page":"2327","article-title":"FTIR and GC\u2010MS Spectral Analysis of Cucumis dipsaceous Ex. Spach. Ehreb Leaves","volume":"7","author":"Anusuba V.","year":"2018","journal-title":"Journal of Pharmacognosy and Phytochemistry"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants11223046"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e30237"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.37398\/JSR.2020.640113"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43094\u2010021\u201000208\u20104"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2024.138866"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/2854217"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2023.105749"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imu.2024.101446"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chnaes.2022.10.004"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/jox11030007"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.6026\/97320630014036"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206828109"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42690\u2010022\u201000932\u20101"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipha.2023.11.012"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43088-022-00310-3"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.9b03157"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13568\u2010024\u201001718\u2010z"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2018.00146"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2022.102688a"},{"key":"e_1_2_10_70_1","volume-title":"Guidelines for Laboratory and Field Testing of Mosquito Larvicide","author":"World Health Organization","year":"2005"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fbio.2022.102123"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2023.11.032"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402475","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T11:13:45Z","timestamp":1744888425000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":71,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/cbdv.202402475"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402475","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]},"assertion":[{"value":"2024-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402475"}}