{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:44:21Z","timestamp":1787165061121,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TU-DSPP-2024-02"],"award-info":[{"award-number":["TU-DSPP-2024-02"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The low effectiveness of currently available antibiotics is driving efforts worldwide to generate new antimicrobial drugs. So, we synthesized some new formazan derivatives containing sulfonamide moiety, and assessed their\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    biochemical properties as well as\n                    <jats:italic>in\u2010vitro<\/jats:italic>\n                    antibacterial activity against some pathogenic Gram\u2010positive (\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    and\n                    <jats:italic>S. aureus)<\/jats:italic>\n                    and Gram\u2010negative (\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>S. thyphi<\/jats:italic>\n                    ) bacteria and fungi (\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and\n                    <jats:italic>A. niger<\/jats:italic>\n                    ). These formazan derivatives were synthesized by condensing sulphanilamide with benzaldehyde in the presence of glacial acetic acid and ethanol produced a Schiff base of sulfonamide (\n                    <jats:bold>1<\/jats:bold>\n                    ). After this compound 1 was reacted with substituted benzene diazonium chlorides (\n                    <jats:bold>2a\u2013g<\/jats:bold>\n                    ) by condensation reaction yields formazan derivatives (\n                    <jats:bold>3a\u2013g<\/jats:bold>\n                    ). The structures of synthesized compounds were characterized on the basis analytical and spectral (IR,\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010NMR, and mass) data. Agar diffusion method was utilized to assess the antibacterial activity of the synthesized compounds by measuring the zone of inhibition against tested strains of bacteria and fungi. Ciprofloxacin and ketoconazole were used as reference drugs. The result exhibited that synthesized compounds have demonstrated satisfactory\n                    <jats:italic>in\u2010silico<\/jats:italic>\n                    biochemical properties as well as significant level of antibacterial activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402488","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T12:23:13Z","timestamp":1729772593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Synthesis,\n                    <i>In\u2010Silico<\/i>\n                    Biochemical Properties, and\n                    <i>In\u2010Vitro<\/i>\n                    Antimicrobial Activity of Some Farmazans\u2010Sulfonamide Derivatives"],"prefix":"10.1002","volume":"22","author":[{"given":"Mazen","family":"Almehmadi","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences Taif University  P.O. Box 11099 21944 Taif Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamdouh","family":"Allahyani","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences Taif University  P.O. Box 11099 21944 Taif Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meshari A.","family":"Alsuwat","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences College of Applied Medical Sciences Taif University  P.O. Box 11099 21944 Taif Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9352-3462","authenticated-orcid":false,"given":"Mohammad","family":"Asif","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Era College of Pharmacy Era University  226003 Lucknow, Uttar Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(01)01255-7"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.40338"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/39.suppl_1.1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.03.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.09.018"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3329\/jsr.v1i3.2589"},{"key":"e_1_2_9_7_1","first-page":"37","volume":"1","author":"Abbas S. 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