{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:18:12Z","timestamp":1790565492324,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Coumarin\u2013chalcone hybrids are promising compounds that could be used as lead structures in the fight against parasitic diseases. In this work, 16 hybrids of coumarin\u2013chalcone (3\u2010cinnamoyl\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010chromen\u20102\u2010ones) were synthesized, and their in vitro biological activity was evaluated against intracellular amastigotes of\n                    <jats:italic>Leishmania braziliensis<\/jats:italic>\n                    and\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    , as well as their cytotoxicity in the U\u2010937 cell line. Compounds (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20103\u2010(3\u2010(3\u2010ethoxy\u20104\u2010hydroxyphenyl)acryloyl)\u20107\u2010methoxy\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010chromen\u20102\u2010one (\n                    <jats:bold>\n                      H\n                      <jats:sub>25<\/jats:sub>\n                    <\/jats:bold>\n                    ) and (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20107\u2010(diethylamino)\u20103\u2010(4\u2010(methoxyphenyl)acryloyl)\u20102\n                    <jats:italic>H<\/jats:italic>\n                    \u2010chromen\u20102\u2010one (\n                    <jats:bold>\n                      H\n                      <jats:sub>12<\/jats:sub>\n                    <\/jats:bold>\n                    ) showed the highest antileishmanial activity with EC\n                    <jats:sub>50<\/jats:sub>\n                    values of 18.6\u00a0\u00b1\u00a03.5 and 25.6\u00a0\u00b1\u00a00.4\u00a0\u00b5M, respectively. In general, all 16 compounds exhibited moderate\u2010to\u2010high antitrypanosomal activity. The\n                    <jats:bold>\n                      H\n                      <jats:sub>25<\/jats:sub>\n                    <\/jats:bold>\n                    hybrid also demonstrated the greatest antitrypanosomal activity, with an EC\n                    <jats:sub>50<\/jats:sub>\n                    value of 13.2\u00a0\u00b1\u00a00.4\u00a0\u00b5M. Notably, the\n                    <jats:bold>\n                      H\n                      <jats:sub>25<\/jats:sub>\n                    <\/jats:bold>\n                    hybrid displayed activity similar to that of benznidazole, which is known for its antiparasitic effects against\n                    <jats:italic>T. cruzi<\/jats:italic>\n                    . The results indicated that all compounds met the drug\u2010like properties criteria. Taking into account the high antiparasitic activity of\n                    <jats:bold>\n                      H\n                      <jats:sub>25<\/jats:sub>\n                    <\/jats:bold>\n                    , a molecular docking study with the enzyme trypanothione reductase was performed. The substituent at C7 in the coumarinyl system is an important structural requirement for the antileishmanial and antitrypanosomal activities.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402515","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T10:41:34Z","timestamp":1734950494000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Antiparasitic Activity of Coumarin\u2013Chalcone (3\u2010Cinnamoyl\u20102\n                    <i>H<\/i>\n                    \u2010Chromen\u20102\u2010Ones) Hybrids"],"prefix":"10.1002","volume":"22","author":[{"given":"Sebasti\u00e1n","family":"Valencia","sequence":"first","affiliation":[{"name":"Facultad de Ciencias, Escuela de Qu\u00edmica Universidad Nacional de Colombia\u2014Sede Medell\u00edn  Medell\u00edn 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