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Despite extensive research, effective treatments remain limited. The indole nucleus, known for its diverse pharmacological properties, has emerged as a promising scaffold for anti\u2010dengue drug discovery. This review comprehensively examines recent advancements in the fields of natural products, medicinal chemistry, and computer\u2010aided drug design focused on discovering indole\u2010based anti\u2010dengue agents. We discuss the rationale for targeting indole frameworks, highlight key structural features associated with anti\u2010dengue activity, and summarize recent research findings. 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