{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:46:16Z","timestamp":1787510776824,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["443973\/2024\u20105"],"award-info":[{"award-number":["443973\/2024\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Alpinia nutans<\/jats:italic>\n                    (L.) Roscoe (Zingiberaceae) is used in folk medicine as an antiviral, anti\u2010inflammatory, and antioxidant. This study aimed to evaluate the seasonality effects on the yield, chemical composition, antioxidant capacity, and anti\u2010Candida activity of the\n                    <jats:italic>A. nutans<\/jats:italic>\n                    essential oil (EO). The specimen was collected monthly for 1 year in Bel\u00e9m, Par\u00e1, Brazil. The leaf EOs were obtained by hydrodistillation and analyzed by gas chromatography\u2013mass spectrometry (GC\/MS), and the antioxidant capacity was evaluated by DPPH and \u03b2\u2010carotene\/linoleic acid. The EO yield showed no significant difference between dry (1.80%\u00a0\u00b1\u00a00.29) and rainy (1.75%\u00a0\u00b1\u00a00.11) seasons. The main chemical constituents identified in the EOs were terpinen\u20104\u2010ol (13.93%\u201323.14%), 1,8\u2010cineole (15.83%\u201318.43%), and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010cymene (14.41%\u201320.16%). Hierarchical cluster analysis (HCA) and principal component analysis (PCA) showed three groups with major constituents in different proportions. None of the samples showed significant inhibition in the DPPH and \u03b2\u2010carotene\/linoleic acid antioxidant method. Analyzing the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), the samples from dry and rainy seasons showed high activity against strains of\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    (MIC 5\u00a0mg\/mL; MFC 10\u00a0mg\/mL),\n                    <jats:italic>Candida parapsilosis<\/jats:italic>\n                    (MIC 2.5\u00a0mg\/mL; MFC 10\u00a0mg\/mL), and\n                    <jats:italic>Candida tropicalis<\/jats:italic>\n                    (MIC 10\u00a0mg\/mL; MFC 10\u00a0mg\/mL). There were only quantitative variations in the chemical composition of\n                    <jats:italic>A. nutans<\/jats:italic>\n                    EO. The anti\u2010Candida potential of the EO was also not influenced by seasonality. The\n                    <jats:italic>A. nutans<\/jats:italic>\n                    EO may be promising to produce anti\u2010Candida phytopharmaceuticals. However, the chemical variability of this species throughout the year should be considered for this purpose.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402530","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T08:50:17Z","timestamp":1734511817000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemometrics of the Seasonal Influence on Chemical Composition, Yield, Antioxidant Capacity, and Anti\u2010Candida Activity of\n                    <i>Alpinia nutans<\/i>\n                    Essential Oil Growing in the Brazilian Amazon Region"],"prefix":"10.1002","volume":"22","author":[{"given":"Raphael O.","family":"de Figueiredo","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica dos Produtos Naturais Universidade do Estado do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Qu\u00edmica Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Caroline S.","family":"Vilhena","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica dos Produtos Naturais Universidade do Estado do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Barbosa","family":"Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica dos Produtos Naturais Universidade do Estado do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kellyane Karen F. A.","family":"Cesar","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia da Rede Bionorte Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Layse F.","family":"Sarrazin","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia da Rede Bionorte Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade Federal do Oeste do Par\u00e1  Santar\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa Helena V.","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia da Rede Bionorte Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Laborat\u00f3rio de Bioprospec\u00e7\u00e3o e Biologia Experimental Universidade Federal do Oeste do Par\u00e1  Santar\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William N.","family":"Setzer","sequence":"additional","affiliation":[{"name":"Aromatic Plant Research Center  Lehi Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce Kelly R.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Qu\u00edmica Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biotecnologia Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-3513","authenticated-orcid":false,"given":"Pablo Luis B.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Qu\u00edmica dos Produtos Naturais Universidade do Estado do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Biodiversidade e Biotecnologia da Rede Bionorte Universidade Federal do Par\u00e1  Bel\u00e9m Par\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-00997-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6RA27830B"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1026(199911\/12)14:6<411::AID-FFJ854>3.0.CO;2-U"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2002.9699904"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2011005000025"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051542"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf104813k"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules29122845"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40659-019-0246-3"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11676-022-01591-1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11676-022-01590-2"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants9101269"},{"key":"e_1_2_9_14_1","volume-title":"Castanha\u2010Da\u2010Amaz\u00f4nia Estud. Sobre a Esp\u00e9cie E Sua Cadeia Valor","author":"Silva L. M.","year":"2023"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41348-021-00511-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.03.038"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2024.104825"},{"key":"e_1_2_9_18_1","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry","author":"Adams R. P.","year":"2007"},{"key":"e_1_2_9_19_1","volume-title":"FFNSC 2: Flavors and Fragrances of Natural and Synthetic Compounds, Mass Spectral Database","author":"Mondello L.","year":"2011"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12173146"},{"key":"e_1_2_9_21_1","unstructured":"C.Belin S.Thomine andJ. I.Schroeder inAbiotic Stress Adapt. Plants eds.A.Pareek S. K.Sopory H.J.BohnertandGovindjee(Dordrecht Netherlands:Springer 2010) 283\u2013305."},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-008-0306-4"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2023.2282580"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ffj.2047"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.32712\/2446-4775.2021.1062"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf030723c"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-022-00960-w"},{"key":"e_1_2_9_28_1","article-title":"Radical Scavenging and Antioxidant Activities of Essential Oil Components \u2013 An Experimental and Computational Investigation","volume":"10","author":"Sharopov F. S.","year":"2015","journal-title":"Natural Products Communications"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scienta.2010.07.011"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03562-9"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf047894h"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2010.9700270"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.08.083"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112259"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.1995.tb05025.x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms6040122"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-158"},{"key":"e_1_2_9_38_1","first-page":"740","article-title":"Biologically Active Hydroxymoyl Chlorides as Antifungal Agents","volume":"47","author":"Ismail T.","year":"2008","journal-title":"Indian Journal of Chemistry Section B\u2010Organic Chemistry Including Medicinal Chemistry"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-010-1050-8"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1684-1182(10)60069-2"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28217259"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1397634"},{"key":"e_1_2_9_43_1","unstructured":"\"INMET Instituto Nacional De Metereologia Brazilian Government \u201c\u00a0An\u00e1lise do Tempo e do Clima accessed September 23 2023 \u201dhttp:\/\/www.inmet.gov.br\/portal."},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2024.107274"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2022.104503"},{"key":"e_1_2_9_46_1","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts","author":"National Committee for Clinical Laboratory Standards (NCCLS)","year":"2002"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/45.4_ts.493"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12132497"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402530","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202402530","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:32:01Z","timestamp":1773009121000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cbdv.202402530"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402530","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"2024-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402530"}}