{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:37:01Z","timestamp":1786977421260,"version":"build-2736575974"},"reference-count":68,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Our study assessed the phytochemical composition and the effects of\n                    <jats:italic>Salvia balansae<\/jats:italic>\n                    flower aqueous extract (FAE) on sexual dysfunction in diabetic rats. Total phenolic and flavonoid content, quantification of phytochemicals by ultrahigh performance liquid chromatography (UHPLC)\u2013electrospray ionization (ESI)\u2013tandem mass spectrometry (MS\/MS) method, and in vitro antioxidant capacity of FAE extract were elucidated. For the in vivo study, diabetes was induced by one intraperitoneal injection of streptozotocin (STZ) (40\u00a0mg\/kg), and treated diabetic rats were given FAE at 200\u00a0mg\/kg. Rats were subjected to a sexual incentive motivation test (SIM) and a mating behavior test, and then serum testosterone levels and sperm quality were analyzed. Our study indicates that FAE contained a large amount of phenolic compounds and flavonoids, and 13 constituents were quantified; cynaroside (3.8\u00a0mg analyte\/g extract) was the main compound, followed by rosmarinic acid (3.145\u00a0mg analyte\/g extract), thus confirming its high antioxidant capacity. FAE treatment significantly reduced blood glucose levels, improved sexual motivation and copulatory behavior, increased testosterone levels, and enhanced sperm quality in diabetic\u2010treated rats compared to diabetic untreated rats. The present work demonstrates the therapeutic potential of\n                    <jats:italic>S. balansae<\/jats:italic>\n                    flowers in enhancing reproductive function in diabetic rats, potentially through its antioxidant, antihyperglycemic, and aphrodisiac properties.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402552","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T03:20:52Z","timestamp":1736220052000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Phytochemical Profiling by UHPLC\u2013ESI\u2013MS\/MS, In Vitro Antioxidant, In Vivo Antidiabetic, and Pro\u2010Sexual Effects of\n                    <i>Salvia balansae<\/i>\n                    No\u00eb Ex Coss. Flower Extract in Diabetic Male Rats"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-5022","authenticated-orcid":false,"given":"Wadjila S.","family":"Souidi","sequence":"first","affiliation":[{"name":"Laboratory of Sciences and Technics of Animal Production, Faculty of Natural and Life Sciences University Abdelhamid Ibn Badis of Mostaganem  Mostaganem Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-7651","authenticated-orcid":false,"given":"Mansouria","family":"Belhocine","sequence":"additional","affiliation":[{"name":"Laboratory of Sciences and Technics of Animal Production, Faculty of Natural and Life Sciences University Abdelhamid Ibn Badis of Mostaganem  Mostaganem 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