{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:37:01Z","timestamp":1786977421400,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Inflammation is an important predisposing factor for many chronic diseases. The dietary flavonoid silibinin (SB) has excellent anti\u2010inflammatory properties in cells, but its low bioavailability in the blood compromises its therapeutic potential. This study aims to investigate the potential of dibenzoylmethane (DBM) to synergistically enhance the anti\u2010inflammatory benefits of SB. The synergistic effects of DBM and SB in combination were evaluated in lipopolysaccharide (LPS)\u2010induced RAW264.7 cells and 12\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010tetradecanoylphorbol 13\u2010acetate (TPA)\u2010induced mice. In addition, a network pharmacology approach and molecular docking were used to explore the key targets and signaling pathways of DBM and SB in combination. The results showed that DBM and SB synergistically inhibited the production of nitric oxide (NO), reactive oxygen species (ROS), interleukin\u20101\u03b2 (IL\u20101\u03b2), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) in a 1:1 concentration ratio. These two compounds may exert their synergistic effects by modulating the nuclear factor kappa\u2010B (NF\u2010\u03baB) and HIF\u20101 signaling pathways, among others. Molecular docking revealed that both compounds exhibited high binding affinities to inducible nitric oxide synthase (iNOS) and cyclooxygenase\u20102 (COX\u20102). Compared with single\u2010compound use, the two compounds in combination significantly reduced ear edema and inflammatory cell infiltration and inhibited the protein expression of iNOS and COX\u20102 in TPA\u2010induced mice. This research provides a rationale for the combination of DBM and SB as an effective anti\u2010inflammatory agent.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402567","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T22:03:17Z","timestamp":1735768997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synergistic Anti\u2010Inflammatory Effects of Dibenzoylmethane and Silibinin: Insights From LPS\u2010Induced RAW 264.7 Cells and TPA\u2010Induced Mouse Model"],"prefix":"10.1002","volume":"22","author":[{"given":"Zebin","family":"Huang","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"},{"name":"School of Food Science and Engineering South China University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Chun","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering Wuyi University Jiangmen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-843X","authenticated-orcid":false,"given":"Yu\u2010Jing","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou China"},{"name":"Guangdong Xianlingtong Biopharmaceutical Technology Co., Ltd Meizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abi5200"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0315-x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.319822"},{"key":"e_1_2_9_3_3","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-018-0126-3"},{"key":"e_1_2_9_3_4","doi-asserted-by":"publisher","DOI":"10.3390\/biom11071011"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9121297"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1678"},{"key":"e_1_2_9_4_3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094540"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.10.049"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-016-0702-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113072"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.202000473"},{"key":"e_1_2_9_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.03.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.12691\/ajps-2-1-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.07.070"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050538"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2016.1208563"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2019.102057"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0040-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.07.027"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12123714"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X1400900127","article-title":"Qualitative Identification of Dibenzoylmethane in Licorice Root (Glycyrrhiza glabra) Using Gas Chromatography\u2010Triple Quadrupole Mass Spectrometry","volume":"9","author":"Mancia M. 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