{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:06Z","timestamp":1753862826383,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012046","name":"Vietnam Academy of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolation and determination of three new compounds from the leaves of <jats:italic>Ailanthus triphysa<\/jats:italic> (Dennst.) Alston with their anti\u2010inflammatory activity. Ten tirucallane triterpenes (<jats:bold>1<\/jats:bold>\u2013<jats:bold>10<\/jats:bold>) including four undescribed compounds, ailantriphysas A\u2013D (<jats:bold>1<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>), were isolated from the leaves of <jats:italic>Ailanthus triphysa<\/jats:italic> (Dennst.) Alston. Their structures were elucidated using IR, HR\u2010ESI\u2010MS, 1D\u2010 and 2D\u2010NMR spectra. Compound <jats:bold>1<\/jats:bold> inhibited lipopolysaccharide(LPS)\u2010induced nitric oxide production in RAW 264.7 cells with an IC<jats:sub>50<\/jats:sub> value of 8.1\u00b1<jats:italic>\u03bc<\/jats:italic>M. Additionally, compound <jats:bold>1<\/jats:bold> also displayed significant inhibitory effects on the secretion of IL\u20106 and TNF\u2010\u03b1 at tested concentrations of 4, 8, and 16\u2005\u03bcM.<\/jats:p>","DOI":"10.1002\/cbdv.202402584","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T09:50:56Z","timestamp":1729677056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Four New Tirucallane Triterpenoids from the Leaves of <i>Ailanthus Triphysa<\/i> with Anti\u2010Inflammatory Activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Nguyen","family":"Duc Duy","sequence":"first","affiliation":[{"name":"Graduate University of Science and Technology VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"},{"name":"Center for High Technology Research and Development VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Thi Dung","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do","family":"Thi Trang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngo","family":"Anh Bang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham","family":"Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Xuan Nhiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Cuc","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phan Thi","family":"Thanh Huong","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Viet Dung","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Huy Hoang","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duong","family":"Thi Hai Yen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"Thi Kim Thuy","sequence":"additional","affiliation":[{"name":"Center for High Technology Research and Development VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen","family":"The Cuong","sequence":"additional","affiliation":[{"name":"Institute of Ecology and Biological Resources VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui","family":"Huu Tai","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"},{"name":"Graduate University of Science and Technology VAST, 18 Hoang Quoc Viet, Cau Giay  Hanoi 10072 Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"e_1_2_9_1_1","unstructured":"V.\u2005V. Chi \u2032The Dictionary of Vietnamese Medicinal Plants\u2032 Medical Publisher Hanoi 2018 2 841\u2013842."},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-009-9157-1"},{"key":"e_1_2_9_3_1","first-page":"154","volume":"34","author":"Shrimali M.","year":"1997","journal-title":"Indian Drugs"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2016.11.007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.20030211204"},{"key":"e_1_2_9_6_1","first-page":"590","volume":"34","author":"Qi S. H.","year":"2003","journal-title":"Zhongcaoyao"},{"key":"e_1_2_9_7_1","first-page":"869","volume":"2","author":"Joshi B. C.","year":"2007","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1572-5995(06)80032-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11710"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(98)00307-0"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.1616"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.56.839"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/np900835k"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0702842"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bse.2023.104668"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2020.07.014"},{"key":"e_1_2_9_17_1","first-page":"154","volume":"34","author":"Shrimali M.","year":"1997","journal-title":"Indian Drugs"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201200079"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(99)00455-0"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100784t"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02575975"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105395"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.113997"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T06:44:06Z","timestamp":1742712246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,14]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cbdv.202402584"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402584","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"type":"print","value":"1612-1872"},{"type":"electronic","value":"1612-1880"}],"subject":[],"published":{"date-parts":[[2024,11,14]]},"assertion":[{"value":"2024-10-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402584"}}