{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T17:11:07Z","timestamp":1791911467954,"version":"4.3.4"},"reference-count":55,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Biebersteinia multifida<\/jats:italic>\n                    DC. is a wild therapeutic plant, traditionally used for various medicinal applications. The aim of the present study is to extract bioactive constituents from the plants' roots and synthesize copper nanoparticles (CuNPs). Ethanolic extraction of the plant's roots yielded 19 bioactive compounds, recognized through gas chromatography\u2013mass spectroscopy (GC\u2010MS), mainly including citraconic anhydride, \u03b3\u2010sitosterol, and 2\u2010furancarboxaldehyde. The prepared CuNPs have been fully characterized. The biological activity evaluations revealed these CuNPs possess acceptable antibacterial and antifungal activities. Furthermore, the CuNPs displayed significant cytotoxic potency toward \u201c4T1 breast cancer cells\u201d while showing a relatively low cell death rate against the normal \u201cHEK\u2010293 kidney cell\u201d. In conclusion, our findings showed that the CuNPs can be synthesized from\n                    <jats:italic>B<\/jats:italic>\n                    .\n                    <jats:italic>multifida<\/jats:italic>\n                    roots with a simple, fast, and eco\u2010friendly procedure. These CuNPs are efficient in antimicrobial and anticancer activities.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402612","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T16:50:15Z","timestamp":1745340615000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Sustainable Antimicrobial and Anticancer Agents: Eco\u2010Friendly Synthesis of Copper Nanoparticles Using\n                    <i>Biebersteinia multifida<\/i>\n                    DC"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2860-0246","authenticated-orcid":false,"given":"Kovan Dilawer","family":"Issa","sequence":"first","affiliation":[{"name":"Medical Analysis Department, Applied Science Faculty Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3011-926X","authenticated-orcid":false,"given":"Hazha Omar","family":"Othman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Salahaddin University\u2010Erbil  Erbil Iraq"},{"name":"Department of Pharmacy Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0561-4365","authenticated-orcid":false,"given":"Hawraz Ibrahim M.","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Salahaddin University\u2010Erbil  Erbil Iraq"},{"name":"Department of Medical Biochemical Analysis Cihan University\u2010Erbil  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahnaz Erfan","family":"Omar","sequence":"additional","affiliation":[{"name":"Medical Analysis Department, Applied Science Faculty Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarya Siraj","family":"Jihad","sequence":"additional","affiliation":[{"name":"Medical Analysis Department, Applied Science Faculty Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danya Dler","family":"Rasool","sequence":"additional","affiliation":[{"name":"Medical Analysis Department, Applied Science Faculty Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah Shahab","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Medical Analysis Department, Applied Science Faculty Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mardin Firsat","family":"Ghazali","sequence":"additional","affiliation":[{"name":"Medical Analysis Department, Applied Science Faculty Tishk International University  Erbil Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1987-8422","authenticated-orcid":false,"given":"Faiq H. 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