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The synthesized derivatives were tested against an array of cancer cell lines, colon HCT\u2010116, breast MCF\u20107, pancreatic MIA PaCa\u20102, and prostate PC\u20103 cancer cell lines. Among the synthesized compounds, <jats:bold>BA1<\/jats:bold> exhibited potent anti\u2010cancer activity with IC<jats:sub>50<\/jats:sub> of 0.84 and 3.87\u00a0\u00b5M against HCT\u2010116 and PC\u20103 using doxorubicin as standard. Our study demonstrates the anti\u2010proliferative and anti\u2010metastatic role of <jats:bold>BA1<\/jats:bold>, thus inducing apoptosis in prostrate and colorectal cell lines.<\/jats:p>","DOI":"10.1002\/cbdv.202402669","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T18:55:48Z","timestamp":1741719348000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Facile Synthesis of Ureidic Derivatives of Betulinic Acid With Antiproliferative Effects on Colorectal and Prostate Cancer Cells"],"prefix":"10.1002","volume":"22","author":[{"given":"Henna","family":"Amin","sequence":"first","affiliation":[{"name":"Bioorganic Chemistry Division Indian Institute of Integrative Medicine (CSIR)  Srinagar India"},{"name":"Academy of Scientific &amp; Innovative Research (AcSIR)  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gursimar","family":"Kaur","sequence":"additional","affiliation":[{"name":"Pharmacology Division CSIR\u2010Indian Institute of Integrative Medicine  Jammu India"},{"name":"Academy of Scientific &amp; 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