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The natural product was assembled from simple commercial reagents via initial domino Knoevenagel\/oxa\u20106\u03c0\u2010electrocyclization followed by epoxidation and an epoxide\/ketone rearrangement promoted by Zn(OTf)2<\/jats:sub>. In vitro cytotoxicity assays identified natural products huajiaosimuline and simulansine as moderate antiproliferative agents against murine colon cancer CT26 cells.<\/jats:p>","DOI":"10.1002\/cbdv.202402680","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T14:39:44Z","timestamp":1733150384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concise Three Step Synthesis of the Bioactive Alkaloid Huajiaosimuline via a Zn(OTf)2<\/sub>\u2010Promoted Meinwald Rearrangement"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7127-2455","authenticated-orcid":false,"given":"Tonino G.","family":"Adessi","sequence":"first","affiliation":[{"name":"Instituto de Qu\u00edmica Rosario Facultad de Ciencias Bioqu\u00edmicas y Farmac\u00e9uticas Universidad Nacional de Rosario\u2010CONICET Rosario Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7148-2484","authenticated-orcid":false,"given":"Enzo F. 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