{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:46:18Z","timestamp":1773013578019,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T00:00:00Z","timestamp":1736208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Long\u2010term use of naproxen can lead to serious side effects. Inspired by the biological activity of cinnamic acid, a series of cinnamic acid derivatives containing naproxen were designed and synthesized, and their anti\u2010inflammatory activities and mechanisms were explored in vitro. Our results indicated that all of naproxen derivatives showed more significant inhibition against lipopolysaccharide (LPS)\u2010induced nitric oxide (NO) production and had a lower degree of cytotoxicity than that of naproxen. The present studies revealed that compound 23 (IC\n                    <jats:sub>50<\/jats:sub>\n                    = 5.66 \u00b1 1.66 \u00b5M) markedly inhibited the LPS\u2010induced NO production and the over\u2010expression of pro\u2010inflammatory cytokines, including interleukin (IL)\u20101\u03b2, inducible NO synthase (iNOS), and cyclooxygenase\u20102 (COX\u20102). Furthermore, it blocked the activation of NF\u2010\u03baB signaling pathway and pyrin domain\u2010containing protein 3 (NLRP\u20103) inflammasome in a concentration\u2010dependent manner. Additionally, docking studies confirmed that compound 23 exhibited a\u00a0well\u2010fitting\u00a0into the NLRP3 active site. Considering these results, compound 23 might be a novel NLRP3 inhibitor to treat inflammatory diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402700","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T02:35:49Z","timestamp":1735526149000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel Cinnamic Acid Derivatives Containing Naproxen as NLRP3 Inhibitors: Synthesis and Evaluation of Their Biological Activity"],"prefix":"10.1002","volume":"22","author":[{"given":"Jialin","family":"Yu","sequence":"first","affiliation":[{"name":"School of Pharmacy and Food Engineering Wuyi University  Jiangmen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zonglin","family":"You","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Food Engineering Wuyi University  Jiangmen 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