{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:08:03Z","timestamp":1790633283951,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Analysis of an antimicrobial extract from the agar\u2010based culture of the marine\u2010derived actinomycete\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    sp. G666 led to the isolation of three new shikimic acid derivatives, streptomine A\u2010C (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ), along with five known compounds (\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ). Their structures were established by their spectral data analyses, including MS and NMR. All the isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Three new compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    demonstrated selective antimicrobial activity against Gram\u2010positive\n                    <jats:italic>Enterococcus faecalis<\/jats:italic>\n                    with MIC values ranging from 32 to 64\u00a0\u00b5g\/mL. Compound\n                    <jats:bold>3<\/jats:bold>\n                    exhibited the highest inhibitory effect against\n                    <jats:italic>E. faecalis<\/jats:italic>\n                    with an MIC value of 32\u00a0\u00b5g\/mL. Compound\n                    <jats:bold>4<\/jats:bold>\n                    selectively inhibited\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    with an MIC value of 128\u00a0\u00b5g\/mL. In addition, compounds\n                    <jats:bold>1\u20133<\/jats:bold>\n                    moderately inhibited the yeast\n                    <jats:italic>Candida albican<\/jats:italic>\n                    s with the same MIC value of 16\u00a0\u00b5g\/mL. Unfortunately, most of isolated compounds were inactive against Gram\u2010negative bacteria\n                    <jats:italic>E. coli, Pseudomonas aeruginosa, and Salmonella enterica<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402701","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T04:30:41Z","timestamp":1734582641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["New Shikimic Acid Derivatives From the Marine\u2010Derived Actinomycete\n                    <i>Streptomyces<\/i>\n                    sp. G666 and Their Antimicrobial Activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Thi Quynh","family":"Do","sequence":"first","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"},{"name":"Faculty of Chemistry Graduate University of Science and Technology, VAST Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Thanh","family":"Van Trinh","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Dao","family":"Phi","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy Linh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Quyen","family":"Vu","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Hong Minh","family":"Le","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy, University of Illinois at Chicago Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3252-870X","authenticated-orcid":false,"given":"Thi Mai Huong","family":"Doan","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"},{"name":"Faculty of Chemistry Graduate University of Science and Technology, VAST Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Van Cuong","family":"Pham","sequence":"additional","affiliation":[{"name":"Institute of Marine Biochemistry Hanoi Hanoi Vietnam"},{"name":"Faculty of Chemistry Graduate University of Science and Technology, VAST Hanoi Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c06307"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113292"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9040436"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA01701F"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01296"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01251-0"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18010022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871520621666210311085748"},{"key":"e_1_2_9_10_1","first-page":"246","volume":"3","author":"Krishnan K.","year":"2014","journal-title":"International Journal of Molecular and Cellular Medicine"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2024.114101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00315"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.957473"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17090529"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1538219"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja0206339"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH9731501"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1135\/cccc19911768"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)90881-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-010-9760-9"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020500480423"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/48.suppl_1.5"}],"container-title":["Chemistry &amp; 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