{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:43Z","timestamp":1786977343159,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T00:00:00Z","timestamp":1735603200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2804203"],"award-info":[{"award-number":["2022YFC2804203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry & Biodiversity"],"published-print":{"date-parts":[[2025,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n Overexpression of a global transcriptional regulator\n LaeA<\/jats:italic>\n was performed to awaken cryptic biosynthetic gene clusters (BGCs) in a marine sponge\u2010derived fungus,\n Aspergillus niger<\/jats:italic>\n L14, to obtain secondary metabolites (SMs), and resulted in the production of five previously undiscovered SMs in the wild\u2010type strain, including three cyclic lipopeptides aspochracin (\n 1<\/jats:bold>\n ), JBIR\u201015 (\n 2<\/jats:bold>\n ) sclerotiotide C (\n 3<\/jats:bold>\n ), kojic acid (\n 4<\/jats:bold>\n ) and penicillic acid (\n 5<\/jats:bold>\n ). Bioassays revealed that compound\n 2<\/jats:bold>\n displayed promising antimicrobial effects on\n Candida albicans<\/jats:italic>\n with a minimum inhibitory concentration value of 32\u00a0\u00b5g\/mL and\n 4<\/jats:bold>\n exhibited significant antioxidant activity with a similar half\u2010maximal inhibitory concentration value (5 \u00b5g\/mL) to that of ascorbic acid. Transcriptome analysis results indicated that the overexpression of\n LaeA<\/jats:italic>\n in strain L14 remarkably enhanced the expression of genes involved in polyketide synthase\u2013non\u2010ribosomal peptide synthetase hybrids and amino acid metabolism, demonstrating an effective approach for the production of cyclic lipopeptides.\n <\/jats:p>","DOI":"10.1002\/cbdv.202402704","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:30:02Z","timestamp":1733977802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Overexpression of the Global Transcriptional Regulator\n LaeA<\/i>\n Leads to Production of Cyclic Lipopeptides in Marine\u2010Derived\n Aspergillus niger<\/i>\n L14"],"prefix":"10.1002","volume":"22","author":[{"given":"Wenjuan","family":"Zhou","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengshi","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Bai","sequence":"additional","affiliation":[{"name":"College of Life and Environmental Sciences Hangzhou Normal University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-3845","authenticated-orcid":false,"given":"Huawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Zhejiang University of Technology Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2916"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.6b00333"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.10.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0121-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2021.126735"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.622785"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10379-4"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17080446"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof8060591"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26165061"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9020261"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.701022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1795-3_6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41477-022-01295-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100198h"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.90228"},{"key":"e_1_2_8_18_1","first-page":"20","article-title":"Studies on the Constituents of Citrusmedica L. var. 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