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This study explores the application of dry crude pomegranate peel extract (PPE) as a bio\u2010input for medicinal gels with wound healing properties. PPE was extracted via percolation in ethanol and freeze\u2010dried. High\u2010performance liquid chromatography and mass spectrometry identified key bioactive compounds: gallic acid, punicalagin, punicalin, ellagic acid, and citric acid, recognized for their antioxidant, antimicrobial, and healing properties. In vitro assays revealed low hemolytic activity, non\u2010cytotoxicity, significant fibroblast proliferation, and robust antioxidant activity (95.99% 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl scavenging at 100\u00a0\u00b5g\/mL). A carbomer gel containing 2.5% w\/w of the extract effectively promoted wound healing in rats, with performance comparable to that of silver sulfadiazine ointment, while demonstrating no microbial contamination during the process. These findings position PPE as a promising, sustainable, and effective alternative for wound\u2010care pharmacotherapy, addressing both medical needs and environmental sustainability.<\/jats:p>","DOI":"10.1002\/cbdv.202402710","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T11:03:54Z","timestamp":1737457434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sustainable Dry Crude Pomegranate Peel Extract as a Bio\u2010input for Medicinal Gels: A Promising Alternative for Wound Healing"],"prefix":"10.1002","volume":"22","author":[{"given":"Rita Cristina Gon\u00e7alves","family":"de Melo","sequence":"first","affiliation":[{"name":"Pharmaceutical Product Development Laboratory Center of Exact, Natural and Health Sciences Federal University of Esp\u00edrito Santo (UFES)  Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vit\u00f3ria 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