{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:06:07Z","timestamp":1773014767193,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T00:00:00Z","timestamp":1746230400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two new glycosylated macrolides (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    ), along with five known compounds (\n                    <jats:bold>3\u20107<\/jats:bold>\n                    ) were isolated from an endophytic bacterium of\n                    <jats:italic>Bacillus velezensis<\/jats:italic>\n                    inhabiting the mangrove plant\n                    <jats:italic>Acanthus ilicifolius<\/jats:italic>\n                    L. Compound\n                    <jats:bold>1<\/jats:bold>\n                    is a 24\u2010membered macrolide featuring a 7\u2010OH glycosylation and a 6\u2019\u2010succinate ester, the C\u20107 epimer of macrolactin D, while compound\n                    <jats:bold>2<\/jats:bold>\n                    is the 7\u2010position epimer of macrolactin B, as determined through comprehensive analysis of one\u2010dimensional and two\u2010dimensional nuclear magnetic resonance, and high\u2010resolution electrospray ionization mass spectra spectroscopic data, as well as chemical transformation. In addition, compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exhibit significant antiviral activity against herpesvirus as determined by quantitative real\u2010time polymerase chain reaction and Western Blot assay. At the messenger RNA level, compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    achieved about 85% inhibition at 5 \u00b5g\/mL, almost equivalent to the positive control of acyclovir.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402748","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T06:40:41Z","timestamp":1745217641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epimeric Macrolactin Analogs From a Marine\u2010Derived\n                    <i>Bacillus velezensis<\/i>\n                    Against Herpesvirus"],"prefix":"10.1002","volume":"22","author":[{"given":"Shuaiqi","family":"Ma","sequence":"first","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuting","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Riaz","sequence":"additional","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaofen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingnan","family":"Qiu","sequence":"additional","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shixin","family":"Li","sequence":"additional","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zou","sequence":"additional","affiliation":[{"name":"Guangzhou Key Laboratory of Drug Research for Emerging Virus Prevention and Treatment, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-5923","authenticated-orcid":false,"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19040180"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2012.724410"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md13085016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.0c01243"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.7b00874"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202001020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.106557"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115495"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)51837-8"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-003-4193-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.0906.06017"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.05.116"},{"key":"e_1_2_8_14_1","first-page":"1","article-title":"Glycoside Compounds From Glycyrrhiza Uralensis and Their Neuroprotective Activities","volume":"16","author":"Wei G. 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