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To date, several main compounds, including coumarins, flavonoids, monoterpene phenols, and benzofurans, have been identified from the seeds of PC. Among them, bavachinin is a type of flavonoid with various biological activities. In this article, the biological activities and mechanisms of action of bavachinin and its derivatives are reviewed. It includes the pharmacokinetic characteristics of bavachinin and its derivatives, as well as its prominent anti\u2010inflammatory, antitumor, antibacterial, and antiviral pharmacological activities and related metabolic studies. Bavachinin displayed these activities through different receptors, such as peroxisome proliferator\u2010activated receptors (PPARs), as well as multiple signaling pathways and enzyme systems. In summary, bavachinin and its derivatives have potential drug development value in many fields, such as anti\u2010inflammatory, antitumor, nervous system disease, and diabetes. We believe that this review will lay a foundation for bavachinin\u2010based drug development throughout the world.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402762","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T11:34:07Z","timestamp":1738064047000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Review of Bavachinin and Its Derivatives as Multi\u2010Therapeutic Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Jun Lin","family":"Zeng","sequence":"first","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine National Engineering Research Center for Modernization of Traditional Chinese Medicine\u2014Hakka Medical Resources Branch School of Pharmacy Gannan Medical University  Ganzhou P. R. China"},{"name":"HuanKui Academy Nanchang University  Nanchang P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Xia","family":"Lan","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine National Engineering Research Center for Modernization of Traditional Chinese Medicine\u2014Hakka Medical Resources Branch School of Pharmacy Gannan Medical University  Ganzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine National Engineering Research Center for Modernization of Traditional Chinese Medicine\u2014Hakka Medical Resources Branch School of Pharmacy Gannan Medical University  Ganzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine National Engineering Research Center for Modernization of Traditional Chinese Medicine\u2014Hakka Medical Resources Branch School of Pharmacy Gannan Medical University  Ganzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine National Engineering Research Center for Modernization of Traditional Chinese Medicine\u2014Hakka Medical Resources Branch School of Pharmacy Gannan Medical University  Ganzhou P. R. 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