{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:46:31Z","timestamp":1784673991133,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by memory decline and cognitive impairments. The clinical treatments for AD have numerous adverse effects; hence, the exploration of natural products for AD therapy is of significant importance. Protocatechuic acid (PA), a natural phenolic acid, has been shown to possess various pharmacological activities, including anti\u2010inflammatory, antioxidant, and antitumor effects. However, the mechanisms underlying its therapeutic potential for AD remain elusive. This study utilized a \u03b2\u2010amyloid (A\u03b2) injection into the hippocampus of mice as an AD model and L\u2010glu\u2010induced HT\u201022 cell neurotoxicity and lipopolysaccharides (LPS)\u2010induced cellular neuroinflammation models to assess reactive oxygen species (ROS), JC\u20101, and relevant biochemical markers. This study examined behavioral, pathological, and inflammatory factors and investigated the molecular mechanisms through transcriptomics, western blot, and molecular docking studies. This study's findings reveal that high\u2010dose PA (50\u00a0mg\/kg) improves symptoms in AD mice through the cholinergic synaptic signaling pathway. This study indicates that PA is a potential candidate for AD treatment targeting the cholinergic synaptic signaling pathway, providing a lead compound for AD therapy.<\/jats:p>","DOI":"10.1002\/cbdv.202402771","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T07:20:02Z","timestamp":1736234402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protocatechuic Acid Improves Alzheimer's Disease by Regulating the Cholinergic Synaptic Signaling Pathway"],"prefix":"10.1002","volume":"22","author":[{"given":"Siwen","family":"Li","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurology China\u2013Japan Union Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasman\u00e9","family":"SEMDE","sequence":"additional","affiliation":[{"name":"Synth\u00e8se des m\u00e9dicaments, CEA\u2010CFOREM Universit\u00e9 Joseph Ki\u2010Zerbo Ouagadougou Burkina Faso"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Teng","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqi","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Lou","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beining","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-3851","authenticated-orcid":false,"given":"Hongyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chinese Medicinal Materials Jilin Agricultural University Changchun China"},{"name":"International Joint Laboratory for Development of Animal and Plant Resources for Food and Medicine Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"issue":"6","key":"e_1_2_8_2_1","first-page":"557","article-title":"Efficacy And Safety of Cholinesterase Inhibitors in Alzheimer's Disease: A Meta\u2010Analysis","volume":"169","author":"Lanct\u00f4t K. 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