{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:47:20Z","timestamp":1773013640566,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two new withanolide derivatives (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ) and 12 known withanolide analogs (\n                    <jats:bold>3<\/jats:bold>\n                    \u2013\n                    <jats:bold>14<\/jats:bold>\n                    ) were identified from the aerial part of\n                    <jats:italic>Physalis angulata<\/jats:italic>\n                    var.\n                    <jats:italic>villosa<\/jats:italic>\n                    Bonati. Their structures were determined by various spectral data, quantum chemical calculations, and sugar derivatization methods. Three compounds (\n                    <jats:bold>2<\/jats:bold>\n                    ,\n                    <jats:bold>3<\/jats:bold>\n                    , and\n                    <jats:bold>14<\/jats:bold>\n                    ) demonstrated good nitric oxide inhibitory effects against lipopolysaccharide\u2010stimulated RAW264.7 cells, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 4.93\u00a0\u00b1\u00a00.22\u20138.58\u00a0\u00b1\u00a00.83\u00a0\u00b5M. The present study suggests that withanolide derivatives have potential anti\u2010inflammatory activity and could be used to treat inflammation\u2010related diseases. Moreover, the chemotaxonomic implications of the isolates are further investigated.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402778","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:24:30Z","timestamp":1736328270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010Inflammatory Withanolides From\n                    <i>Physalis angulata<\/i>\n                    Var.\n                    <i>villosa<\/i>\n                    Bonati"],"prefix":"10.1002","volume":"22","author":[{"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Guizhou Medical University  Guiyang People's Republic of China"},{"name":"Natural Products Research Center of Guizhou Province  Guiyang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Zhi","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Guizhou Medical University  Guiyang People's Republic of China"},{"name":"Natural Products Research Center of Guizhou Province  Guiyang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University  Guiyang People's Republic of China"},{"name":"School of Pharmaceutical Sciences Guizhou Medical University  Guiyang People's Republic of China"},{"name":"Natural Products Research Center of Guizhou Province  Guiyang People's Republic of 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