{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:04:01Z","timestamp":1784804641314,"version":"3.55.0"},"reference-count":117,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T00:00:00Z","timestamp":1739664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This review article provides an inclusive overview of the intricate interactions amid ionic liquids (ILs) and essential biomacromolecules, mainly hemoglobin (Hb), bovine serum albumin (BSA), human serum albumin (HSA), and calf thymus\u2010DNA (CT\u2010DNA). ILs have recently become a topic of great attention because of their inimitable physicochemical properties and potential uses in different fields. The review systematically explores the binding mechanisms, thermodynamics, and structural changes induced by ILs on Hb, BSA, HSA, and CT\u2010DNA using spectroscopic, thermodynamic, and computational techniques. The article highlighted various experimental and computational methodologies to explore the interactions between ILs and biomacromolecules. It offers an in\u2010depth analysis of the techniques employed to decode the intricate nature of these molecular associations and the influence of ILs along with their structural characteristics on the conformational stability, activity, and functionality of biomacromolecules. This foundational understanding is essential for advancing research and developing strategies that exploit the distinctive properties of ILs to foster innovative and sustainable applications within the biomedical field.<\/jats:p>","DOI":"10.1002\/cbdv.202402781","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T10:39:42Z","timestamp":1737974382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring Biophysical and Chemoinformatics Approaches for Interactions of Ionic Liquids With Hemoglobin, DNA, BSA, and HSA"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-098X","authenticated-orcid":false,"family":"Sangeeta","sequence":"first","affiliation":[{"name":"Department of Chemistry Netaji Subhas University of Technology  Dwarka Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Mehra","sequence":"additional","affiliation":[{"name":"Department of Applied Chemistry Bhagwan Parshuram Institute of Technology, GGSIPU  Rohini Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjana","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Netaji Subhas University of Technology  Dwarka Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-6702","authenticated-orcid":false,"given":"Ravi","family":"Tomar","sequence":"additional","affiliation":[{"name":"Department of Chemistry SRM Institute of Science &amp; Technology, Delhi\u2010NCR Campus, Modinagar  Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u201062703\u2010398\u20105_12"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.123"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003\u20102697(89)90213\u20103"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2014.09.001"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2013.05.009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/C3PY01648J"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12088\u2010024\u201001266\u2010x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201004\u2010078188"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar9603064"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2023.10.063"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202400891"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13307"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1953.018.01.020"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2008.07.012"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201500603"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vacuum.2016.11.029"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1280"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010018\u20100422\u20107"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2023.341502"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2016.07.044"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00562"},{"key":"e_1_2_13_23_1","volume-title":"Biocompatibility of Ionic Liquids Towards Protein Stability: A Comprehensive Overview on the Current Understanding and Their Implications","author":"Kumar A.","year":"2017"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12010\u2010014\u20100813\u20106"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s41061\u2010017\u20100110\u20102"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2023.2253470"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.123325"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202204535"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.31788\/RJC.2023.1648581"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.112525"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010018\u20100407\u20106"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2016.02.011"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200905981"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1039\/b107270f"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201032539\u2010y"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.62593\/2090\u20102468.1009"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010024\u201058321\u20102"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1gc15334j"},{"key":"e_1_2_13_39_1","unstructured":"P. C. A.PintoandM. L. M. F.SaraviaIonic Liquids: A Pharmaceutical Perspective \"In Ionic Liquids: Synthesis Characterization and Applications \" Brooks A. Ed.; Nova Science Publishers Inc. 2014."},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201100036"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/B110838G"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cc02021a"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.3998\/ark.5550190.0009.h06"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12551\u2010018\u20100419\u20102"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.est.2022.105932"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/157019312800604698"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/528188a"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk\u20102010\u20101038.ch001"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1039\/b006677j"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.808185"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.3c00384"},{"key":"e_1_2_13_52_1","first-page":"24","article-title":"Review \/Preview: Prodrug Ionic Liquids Combining the Prodrug and Ionic Liquid Strategies to Active Pharmaceutical Ingredients","volume":"31","author":"Cojocaru O. A.","year":"2013","journal-title":"Chim Oggi\u2010Chemistry Today"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7ra00075h"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.2841"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c080113"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00265a036"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1997.1087"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125270"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2012.09.015"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2016.08.031"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2008.10.010"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/am404069f"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2014.09.014"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cp54398f"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17781"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra00036j"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.5b02031"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5b04660"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.5b00939"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.112450"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.116710"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2021.118213"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125791"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124227"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2023.122837"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2023.110762"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2022.2159878"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2018.04.115"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2014.10.017"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786435.2015.1119323"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.5b01385"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200906610"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp9104757"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4cp01159g"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2017.04.068"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c02530"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.08.106"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm5018029"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2016.09.040"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.5b02939"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr8010013"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1002\/tcr.201600121"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.09.016"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfa.2017.07.082"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlumin.2014.09.021"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2019.07.096"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2015.10.023"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2009.10.001"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20101009.1000265"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2018.09.001"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2019.127591"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.113695"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111971"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.9b06194"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.7b03457"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.114537"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.124284"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2020.114078"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.125883"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp400079p"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973\u2010020\u201010111\u20104"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.2c03472"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2024.126002"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.1c08595"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.2c02963"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev\u2010chembioeng\u2010060713\u2010040024"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42250\u2010024\u201000960\u2010z"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11581\u2010025\u201006082\u2010x"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402781","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202402781","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202402781","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:07:36Z","timestamp":1773227256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202402781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,16]]},"references-count":117,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/cbdv.202402781"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202402781","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,16]]},"assertion":[{"value":"2024-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e202402781"}}