{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:22:04Z","timestamp":1781731324952,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The emergence of multiple drug\u2010resistant bacteria poses critical health threats worldwide. It is urgently needed to develop potent and safe antibacterial agents with novel bactericidal mechanisms to treat these infections. In this study, magnolol was identified as a potential bacterial cell division inhibitor by a cell\u2010based screening approach. This compound showed good antibacterial activity against a number of Gram\u2010positive pathogens (minimum inhibitory concentration 8\u201316 \u00b5g\/mL) including methicillin\u2010resistant\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and vancomycin\u2010resistant\n                    <jats:italic>Enterococcus<\/jats:italic>\n                    . Further results obtained from biochemical experiments demonstrated that magnolol could markedly disrupt GTPase activity and filamentous temperature\u2010sensitive mutant Z (FtsZ) polymerization, consistent with the impediment to cell division in the bacteria tested. The in vivo antibacterial activity of magnolol was evaluated with a\n                    <jats:italic>Galleria mellonella<\/jats:italic>\n                    larvae model. The results showed that magnolol significantly increased the survival rate of larvae infected with methicillin\u2010resistant\n                    <jats:italic>S. aureus<\/jats:italic>\n                    . The interaction pattern of magnolol with FtsZ was investigated through molecular docking. The finding may offer meaningful insights into the mechanism of action of the compound. The results point to magnolol as a promising antimicrobial compound that inhibits cell division by affecting FtsZ polymerization and has the potential to be developed into an effective antimicrobial drug by further structure modification.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402800","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:25:01Z","timestamp":1734956701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Magnolol as an Antibacterial Agent Against Drug\u2010resistant Bacteria Targeting Filamentous Temperature\u2010sensitive Mutant Z"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3500-9163","authenticated-orcid":false,"given":"Ning","family":"Sun","sequence":"first","affiliation":[{"name":"Guangzhou 11th People's Hospital, Guangzhou Cadre and Talent Health Management Center Guangzhou P. R. 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