{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:06:19Z","timestamp":1774379179081,"version":"3.50.1"},"reference-count":102,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mucormycosis, a life\u2010threatening fungal infection caused by Mucorales, affects immunocompromised patients, especially SARS\u2010CoV\u20102 ones. Existing antifungal therapies, like amphotericin B, have serious health risks. The current study reviews the literature regarding an overview of SARS\u2010CoV\u20102\u2010associated mucormycosis, along with different terpenes from diverse edible sources, such as basil, ginger, and clove, which are detected till June 2024. The antifungal potential of collected terpenes, their classifications, mechanisms of action, minimum inhibitory concentration (MIC) values, and future perspectives are discussed here. The search identified 89 fungicidal volatile terpenes, belonging to about 26 families, from which 45 were selected for further in silico analysis. The results highlighted oryzalexin B (60), oryzalexin D (62), carvacrol (4), mansorin B (66), muzigadial (86), and lubimin (80) as potential antifungal agents against lanosterol 14\u03b1\u2010demethylase, CotH3, and mucoricin as potential targets in Mucorales. CotH3 is crucial for activating GRP\u201078, a host co\u2010receptor for ACE2, which is essential for SARS\u2010CoV\u20102 pathogenesis. Additionally, carvacrol was in vitro investigated against\n                    <jats:italic>Mucor racemosus<\/jats:italic>\n                    via the agar diffusion method, giving an MIC value of 1\u00a0mg\/mL, compared to 0.1\u00a0mg\/mL of ketoconazole. This study suggests promising potential for volatile terpenes in combating SARS\u2010CoV\u20102\u2010associated mucormycosis, with the need for further refined in vitro and in vivo studies to establish clinical efficacy.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402847","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T11:30:01Z","timestamp":1737718201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Unveiling the Broad\u2010Spectrum Efficacy of Volatile Terpenes to Fight Against SARS\u2010COV\u20102\u2010Associated Mucormycosis"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5517-082X","authenticated-orcid":false,"given":"Eman Maher","family":"Zahran","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethar","family":"Elfoly","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyad Y.","family":"Elhamadany","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad S.","family":"Hemied","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek A.","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Hisham","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-6922","authenticated-orcid":false,"given":"Usama Ramadan","family":"Abdelmohsen","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Deraya University, Universities Zone  New Minia City Egypt"},{"name":"Deraya Center for Scientific Research Deraya University, Universities Zone  New Minia City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,14]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"72","article-title":"A Successful Treatment of Rhinocerebral Mucormycosis Due to Rhizopus oryzae","volume":"19","author":"Mohammadi R.","year":"2014","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"key":"e_1_2_13_3_1","first-page":"69341","volume-title":"Environmental Science and Pollution Research","author":"Islam M. 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