{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:19:08Z","timestamp":1789003148137,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360687"],"award-info":[{"award-number":["82360687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Further phytochemical investigation on the twigs of\n                    <jats:italic>Trichilia connaroides<\/jats:italic>\n                    led to the isolation of nine limonoids (\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>2<\/jats:bold>\n                    , and\n                    <jats:bold>5\u201311<\/jats:bold>\n                    ), one 3,4\u2010seco\u2010homo\u2010cycloartane (\n                    <jats:bold>3<\/jats:bold>\n                    ), and two steroids (\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>12<\/jats:bold>\n                    ). The structures of these obtained isolates were established by means of detailed analyses of their extensive spectroscopic information and electronic circular dichroism calculations, four of them were elucidated as undescribed compounds (\n                    <jats:bold>1\u20134<\/jats:bold>\n                    ). It is noted that an unprecedented 7\u2010oxabicyclo[2.2.1]\u2010heptane moiety in trichilitin M (\n                    <jats:bold>1<\/jats:bold>\n                    ) was proposed by the linkage of C\u201011 and C\u201014 via an oxygen atom. All compounds were evaluated for their anti\u2010tobacco mosaic virus (anti\u2010TMV) activities by the conventional half\u2010leaf method and reverse transcription polymerase chain reaction (RT\u2010PCR) assays. Compared with the positive control ningnanmycin, compounds\n                    <jats:bold>1<\/jats:bold>\n                    ,\n                    <jats:bold>6<\/jats:bold>\n                    ,\n                    <jats:bold>7<\/jats:bold>\n                    , and\n                    <jats:bold>11<\/jats:bold>\n                    showed significant anti\u2010TMV biological activities. Furthermore, quantitative RT\u2010PCR assays suggested that the expression level of the TMV coat protein (CP) gene in inoculated and systemic K326 leaves treated by both\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    , was significantly lower than that for the control group. More importantly, compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    could not only inhibit the accumulation of the TMV CP gene but also enhance the host plant's resistance to TMV infection.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202402850","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T20:16:54Z","timestamp":1739218614000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chemical Constituents From\n                    <i>Trichilia connaroides<\/i>\n                    and Their Anti\u2010Tobacco Mosaic Virus Properties"],"prefix":"10.1002","volume":"22","author":[{"given":"Qin\u2010Dan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En\u2010Ming","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines Kunming Institute of Botany, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Tong","family":"Di","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines Kunming Institute of Botany, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zou","sequence":"additional","affiliation":[{"name":"The School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu\u2010Jie","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Phytochemistry and Natural Medicines Kunming Institute of Botany, Chinese Academy of Sciences  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&amp;D, Guizhou Medical University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Dictionary of Chinese Crude Drugs","author":"Jiangsu New Medical College","year":"1977"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np100428u"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol5027552"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b00346"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2NP00015F"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr9004023"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.95.027"},{"key":"e_1_2_11_9_1","first-page":"1849","article-title":"Progress in the Study of Rotenone Derivatives","volume":"28","author":"Zhou Z. 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