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Molecular docking analysis showed strong binding affinities of benzoxazoles toward Akt and nuclear factor kappa B (NF\u2010\u03baB) protein targets that promote cancer cell proliferation and survival and whose expression is linked to tumorigenesis of activated B\u2010cell (ABC) and germinal center B\u2010cell (GCB) DLBCL subtypes. WST\u20108 assay showed the highest inhibitory activity of benzoxazole derivative bearing thiophene substituent in both DLBCL models. Western blot analysis indicated the inhibitory activity of selected compounds in HBL\u20101 cells, with decreased <jats:italic>p<\/jats:italic>\u2010NF\u2010\u03baB and <jats:italic>p<\/jats:italic>\u2010Akt protein expression, whereas treatment of DHL\u20104 cells stimulated the expression of <jats:italic>p<\/jats:italic>\u2010Akt and <jats:italic>p<\/jats:italic>\u2010NF\u2010\u03baB protein levels. These data suggest distinct, cell line\u2010dependent activities of the substances that potentially act through diverse oncogenic signaling pathways in DLBCL cells and activation of compensatory cell mechanisms that could be an important step for combinatorial treatment approaches.<\/jats:p>","DOI":"10.1002\/cbdv.202402853","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T21:34:29Z","timestamp":1748381669000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting Lymphoma With Benzoxazole Derivatives: Effects on Viability and Protein Expression in Cell Lines"],"prefix":"10.1002","author":[{"given":"Esma","family":"Bilajac","sequence":"first","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering and Natural Sciences International University of Sarajevo  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1206-6990","authenticated-orcid":false,"given":"Una","family":"Glamo\u010dlija","sequence":"additional","affiliation":[{"name":"University of Sarajevo\u2014Faculty of Pharmacy  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lejla","family":"Mahmutovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering and Natural Sciences International University of Sarajevo  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abas","family":"Sezer","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering and Natural Sciences International University of Sarajevo  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elma","family":"Veljovi\u0107","sequence":"additional","affiliation":[{"name":"University of Sarajevo\u2014Faculty of Pharmacy  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma","family":"\u0160pirtovi\u0107\u2010Halilovi\u0107","sequence":"additional","affiliation":[{"name":"University of Sarajevo\u2014Faculty of Pharmacy  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirsada","family":"Salihovi\u0107","sequence":"additional","affiliation":[{"name":"University of Sarajevo\u2014Faculty of Pharmacy  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirha","family":"Pazalja","sequence":"additional","affiliation":[{"name":"University of Sarajevo\u2014Faculty of Pharmacy  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Altijana","family":"Hromi\u0107\u2010Jahjefendi\u0107","sequence":"additional","affiliation":[{"name":"Department of Genetics and Bioengineering Faculty of Engineering and Natural Sciences International University of Sarajevo  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amar","family":"Osmanovi\u0107","sequence":"additional","affiliation":[{"name":"University of Sarajevo\u2014Faculty of Pharmacy  Sarajevo Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1080\/07357907.2018.1477955","article-title":"Biology of Cancer; From Cellular Cancerogenesis to Supracellular Evolution of Malignant Phenotype","volume":"36","author":"Motofei I. 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